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p38 MAPK regulates Th2 cytokines release in PBMCs in allergic rhinitis rats |
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| Authors: | Jie Liu Lisi Liu Yonghua Cui Jian Zhang Hongqun Jiang |
| Affiliation: | 1. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China 2. Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3. Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China |
| Abstract: | Th2 cytokines play a pivotal role in the pathogenesis of allergic rhinitis.To investigate the effect of p38 mitogen-activated protein kinase(MAPK) on the production of Th2 cytokines such as IL-4 and IL-5 in allergic rhinitis,a model of allergic rhinitis was established in SD rats.The expression level of p38 MAPK mRNA in PBMCs was detected by means of real time quantitative RT-PCR.The p38 MAPK activity in PBMCs was detected by Western blotting.PBMCs were cultured with various concentrations of p38 MAPK inhib... |
| Keywords: | allergic rhinitis p38 MAPK SB 239063 |
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