桑通颗粒的主要药效学研究

目的:观察桑通颗粒的止咳、祛痰、平喘作用。方法:将实验动物随机分为5组,即空白对照组,桑通颗粒高、中、低剂量组和阳性对照组;采用氨水引咳法观察桑通颗粒对致咳小鼠模型的影响;采用酚红排泌试验观察桑通颗粒的祛痰作用;采用磷酸组胺-乙酰胆碱引喘法观察桑通颗粒对致喘豚鼠模型的影响。结果:与空白对照组比较,桑通颗粒各治疗组致咳潜伏期和引喘潜伏期明显延长,咳嗽次数明显减少,酚红排泌量明显增加(P<0.05或P<0.01);桑通颗粒各组与阳性对照组比较,差别无统计学意义(P>0.05)。结论:桑通颗粒具有较好的止咳、祛痰、平喘的作用。

The Experimental Study on Main Pharmacodynamics of Sangtong Granule

Objective：To observe the antitussive,expectorant and antiasthmatic actions of Sangtong granule.Methods：The experimental animals were randomized into 5 groups：control group,high-,moderate-and low-dose Sangtong granule groups,positive control group.the effect of Sangtong Granule on cough mice were observed by the method of strong aqua causing cough;the fuction of eliminating phlegm were observed by phenol red excrete;the effect of Sangtong Granule on bronchial asthma cavia cobaya were observed by the method of histamine phosphate causing asthma.Results：Compared with control group,the stage of latency of cough and asthma were extend,the frequency of cough were decreased,and the quantity of phenol red excrete were increased（P〈0.05 or P〈0.01）;There was no significant difference between Sangtong granule groups and positive control group（P〉0.05）.Conclusion：Sangtong granule has certain antitussive,expectorant and antiasthmatic actions.