| BALB/C小鼠免疫耐受模型建立及移植人体肺癌初步研究 |
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| 引用本文： | 任金荣,郑振海,王增林,刘鹿宁,于凤玲.BALB/C小鼠免疫耐受模型建立及移植人体肺癌初步研究[J].癌变．畸变．突变,2003,15(1):25-27. |
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| 作者姓名： | 任金荣 郑振海 王增林 刘鹿宁 于凤玲 |
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| 作者单位： | 1. 河北医科大学第四医院,河北省肿瘤研究所,河北,石家庄,050011
2. 河北灵寿郑氏生物癌研究所,河北,灵寿县,050500 |
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| 摘 要： | 目的：获得一种能移植人体肿瘤并存活的动物模型。方法：将郑氏植物蛋白（ZPP）0.1ml皮下注射BALB／C小鼠，诱导其免疫耐受性移植人体肺肿瘤组织。结果：移植肺肿瘤在模型动物体内存活，成功率可达65％（26／40），而对照组小鼠体内移植瘤全部被排斥，不能存活。结论：ZPP可引起小鼠对人体肺肿瘤细胞免疫耐受，使移植瘤成活。
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| 关 键 词： | BALB／C小鼠 免疫耐受 肺肿瘤 移植 郑氏植物蛋白 |
| 文章编号： | 1004-616X(2003)01-0025-03 |
| 修稿时间： | 2001年9月21日 |
ESTABLISHMENT OF IMMUNE TOLERANCE MODEL IN BALB/C MOUSE AND PRELIMINARY STUDY ON THE TRANSPLANTING HUMAN LUNG CANCER |
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| Abstract: | Purpose: To obtain an animal model in which the human lung tumor may successfully be transplanted and survival. Methods: In new born BALB / C mice the immune tolerance was induced by injecting Zheng's plant_protein (ZPP), and then the human lung tumor tissues were transplanted into the mice. Results: 65 % (26 / 40) of the transplanted human lung tumor tissues were survival whereas in the control mice the transplanted tumors were totally rejected. Conclusion: ZPP may induce immune tolerance in BALB / C mouse and the transplanted human lung cancer may be survival in the mouse. |
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| Keywords: | BALB / C mice Immune tolerance Lung tumor Transplanting Zheng's plant protein |
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