| 定量PCR技术检测增生性瘢痕组织纤维连接蛋白的基因表达 |
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| 引用本文： | 杨银辉,付小兵,王亚平,孙同柱,许明火,盛志勇. 定量PCR技术检测增生性瘢痕组织纤维连接蛋白的基因表达[J]. 中华整形外科杂志, 1998, 0(6) |
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| 作者姓名： | 杨银辉 付小兵 王亚平 孙同柱 许明火 盛志勇 |
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| 作者单位： | Yang Yinhui，Fu Xiaobing，Wang Yaping，et al. Wound Healing Unit，Burns Institute，The 304th Hospital，Beijing 100037 |
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| 摘 要： | 目的探讨纤维连接蛋白的表达水平与创伤后增生性瘢痕形成的关系。方法采用定量ＰＣＲ技术，对纤维连接蛋白（Ｆｉｂｒｏｎｅｃｔｉｎ，ＦＮ）在正常皮肤和增生性瘢痕中ｍＲＮＡ表达水平的变化进行比较。结果在增生性瘢痕中，ＦＮ的ｍＲＮＡ表达水平较正常皮肤增高。结论实验结果表明细胞外基质成分的变化在创伤修复失控形成中起重要作用。
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| 关 键 词： | 创伤修复 纤维连接蛋白 增生性瘢痕 定量PCR |
Fibronectin mRNA expression in hypertrophic scars |
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| Yang Yinhui,Fu Xiaobing,Wang Yaping,et al.. Fibronectin mRNA expression in hypertrophic scars[J]. Chinese journal of plastic surgery, 1998, 0(6) |
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| Authors: | Yang Yinhui Fu Xiaobing Wang Yaping et al. |
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| Affiliation: | Yang Yinhui,Fu Xiaobing,Wang Yaping,et al. Wound Healing Unit,Burns Institute,The 304th Hospital,Beijing 100037 |
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| Abstract: | Objective This study was to compare the content of fibronectin messenger RNA in the normal skin and hypertrophic scars.Method The mRNA levels of fibronectin were measured by quantitative RT PCR.Result The study revealed that in vivo,the content of fibronectin messenger RNA was higher in hypertrophic scars than in normal skin.Conclusion It indicates that altered regulation of extracellular matrix components is an important factor for abnormal human wound healing. |
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| Keywords: | Wound healing Fibronectin Hypertrophic scar Quantitative RT PCR |
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