| 老年心脏病患者血清柯萨奇病毒B特异性抗体和核酸的检测 |
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| 引用本文： | 孙芸芸,蒋文玲,罗宪玲. 老年心脏病患者血清柯萨奇病毒B特异性抗体和核酸的检测[J]. 南方医科大学学报, 2004, 24(5): 572-573 |
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| 作者姓名： | 孙芸芸 蒋文玲 罗宪玲 |
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| 作者单位： | 广东省心血管病研究所,广东,广州,510100;广东省老年医学研究所,广东,广州,510080 |
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| 基金项目： | 广东省科技攻关项目(99MO4608G)~~ |
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| 摘 要： | 目的了解柯萨奇B组病毒(CVB)在老年人中的感染状况,探讨CVB感染与心血管疾病的内在关系。方法采用间接酶联免疫吸附试验(ELISA)和反转录PCR方法对230例老年人进行了CVB IgG 抗体和核酸检测。结果心脏病组CVB IgG抗体阳性率为43.61%(75/172),对照组抗体阳性率为15.52%(9/58),两者比较有显著性差异(P<0.01)。CVB RNA 检测结果显示,心脏病组阳性率为20.93%(36/172),对照组为3.45%(25/58),两者比较有显著性差异(P<0.01)。结论在老年心脏病患者中CVB感染较为普遍,应引起重视。
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| 关 键 词： | 柯萨奇病毒B 间接酶联免疫吸附试验 反转录PCR 心脏病 老年人 |
| 文章编号： | 1000-2588(2004)05-0572-02 |
| 修稿时间： | 2004-02-16 |
Detection of serum coxsackievirus B-specific antibody and nucleic acid in aged patients with cardiopathy |
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| SUN Yun-yun,JIANG Wen-lin,LUO Xian-lingGuangdong Cardiovascular Institute of Guangdong Province,Guangzhou ,China, Guangdong Geriatrics Institute of Guangdong Province,Guangzhou ,China. Detection of serum coxsackievirus B-specific antibody and nucleic acid in aged patients with cardiopathy[J]. Journal of Southern Medical University, 2004, 24(5): 572-573 |
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| Authors: | SUN Yun-yun JIANG Wen-lin LUO Xian-lingGuangdong Cardiovascular Institute of Guangdong Province Guangzhou China Guangdong Geriatrics Institute of Guangdong Province Guangzhou China |
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| Affiliation: | SUN Yun-yun1,JIANG Wen-lin2,LUO Xian-ling21Guangdong Cardiovascular Institute of Guangdong Province,Guangzhou 510100,China, 2Guangdong Geriatrics Institute of Guangdong Province,Guangzhou 510080,China |
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| Abstract: | Objective To understand the status of coxsackievirus B (CVB) infection in senior subjects and explore the association of the infection with cardiovascular diseases. Method By means of ELISA and RT-PCR, CVB IgG antibody and nucleic acid were detected in 172 patients with cardiopathy and 58 control subjects. Results The positivity rate of CVB IgG antibody was 43.61% (75/172) in the patient group and 15.52% (9/58) in the control group, showing obvious difference between the two groups. CVB RNA tests revealed a CVB RNA-positivity rate of 20.93% (36/172) in the former group and 3.45%(2/58) in the latter, with also a significant difference (P<0.01). Conclusion CVB infection is prevalent in aged patients with heart disease, which should be given due attention to. |
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