25-羟维生素D与妊娠期高血压疾病相关性的研究

目的研究25-羟维生素D(25-OH-VitD)与妊娠期高血压疾病之间的相关性。方法采用电化学发光免疫分析法筛查1 100例12~18孕周孕妇的血清中25-OH-VitD表达水平,同时分析25-OH-VitD与妊娠期高血压疾病发病的相关性。结果在该院筛查的1 100例孕妇中,在该院分娩的产妇有1 000例,其中101例产妇患妊娠期高血压疾病,其中妊娠期高血压41例,轻度子痫前期32例,重度子痫前期28例,发病率为10.1%。健康孕妇、轻度子痫前期孕妇、重度子痫前期孕妇的25-OH-VitD血清表达水平分别为(19.5±3.3)、(12.5±1.5)、(9.5±1.2)ng/mL。健康孕妇与妊娠期高血压患者外周血中的25-OH-VitD表达水平差异无统计学意义(P0.05),重度子痫前期患者与轻度子痫前期患者血清25-OH-VitD表达水平均明显低于健康孕妇,差异有统计学意义(P0.05)。结论 25-OH-VitD的降低与子痫前期的发病密切相关,并且在子痫前期临床症状发生之前出现异常,可能成为子痫前期的一项预测性标志物。

Relationship between 25-OH vitamin D and gestational hypertension disease

Objective To investigate the correlation between 25-OH vitamin D and gestational hypertension disease .Methods The serum 25-OH vitamin D level in 1 100 cases of pregnant women during 12 - 18 weeks of pregnancy were detected .The correla-tion between 25-OH vitamin D and gestational hypertension disease were analyzed .Results A total of 1 000 pregnant women gave a birth to a child in our hospital ,and 101 pregnant women suffered with gestational hypertension disease ,including 41 cases suffered with gestational hypertension ,32 cases suffered with mild preeclampsia ,28 cases suffered with severe preeclampsia ,the incidence was 10 .1% .the serum 25-OH vitamin D levels of normal pregnant women ,patients with mild preeclampsia and severe preeclampsia were(19 .5 ± 3 .3) ,(12 .5 ± 1 .5)and(9 .5 ± 1 .2)ng/mL respectively .The 25-OH vitamin D levels had no significant difference be-tween normal pregnant women and women with gestational hypertension(P > 0 .05) .The 25-OH vitamin D levels in severe pre-eclampsia patients and mild preeclampsia patients were significant lower than that of normal pregnant women ( P < 0 .05 ) . Conclusion The lower level of 25-OH vitamin D is associated with preeclampsia ,it is found earlier than the emergence of clinical symptoms of preeclampsia ,25-OH vitamin D might be a marker of predicting preeclampsia .