探讨血清视黄醇结合蛋白和胱抑素C在肾脏疾病中的诊断价值

目的：探讨血清视黄醇结合蛋白（retinol blinding protein ，RBP）和胱抑素C（Cystatin C ，CysC）联合检测在肾脏疾病中的临床诊断价值。方法采用Beckman‐Coulter全自动生化仪分别检测173例肾病患者和50例健康体检者的血清尿素氮（U‐rea）、肌酐（Cr）、尿酸（UA）、视黄醇结合蛋白（RBP）、胱抑素C（CysC）的含量，并进行相关的统计学分析。结果173例肾病患者的RBP浓度为（70．86±14．41）mg／L ，CysC浓度为（3．41 ± 0．65）mg／L ，对照组RBP浓度为（41．36±5．68）mg／L ，CysC浓度为（0．98 ± 0．20）mg／L ，肾病组明显高于对照组（P＜0．05）。各疾病组 Cysc的检出阳性率最高，RBP次之，二者联合检测阳性率更高，明显高于传统肾功能指标Urea、Cr、UA。结论血清视黄醇结合蛋白和胱抑素C可作为诊断肾脏疾病的敏感指标，二者联合检测可提高诊断阳性率。

Discussion on the clinical diagnostic value of joint detection with serum cystatin c (cysc) and retinol binding protein (RBP)in nephropathy

Objective Discussion on the clinical diagnostic value of joint detection with serum cystatin C (cysC)and retinol bind‐ing protin(RBP)in nephropathy .Methods CysC and RBP were detected in 173 nephropathy patinents and 50 controls with Beck‐man auto chemistry analyzer .Urea Cr and UA were detected at the same time with related statistical analysis .Results ⑴RBP level was significantly higher in 173 nephropathy patients than the healthy controls [(70 .86 ± 14 .41)mg/L and(41 .36 ± 5 .68)mg/L re‐spectively ,P<0 .05] .CysC level was significantly higher in 173 nephropathy patients than the healthy controls [(3 .41 ± 0 .65)mg/L and(0 .98 ± 0 .20)mg/L respectively ,P<0 .05] .(2)The positivity rate of CysC was highest ,followed by RBP .And the positivity rate of joint detection serum CysC and RBP was higher ,significantly higher than that of the traditional renal function indexes (inclu‐ding Urea ,Cr ,UA) .Conclusion Either RBP or CysC can be used as a sensitive index for diagnosis of renal disease .The combined detection of RBP and CysC can be more helpful for the diagnostic yield .