健脑止抽颗粒辅助氟哌啶醇治疗抽动障碍疗效及对T细胞的影响研究

目的探讨健脑止抽颗粒辅助氟哌啶醇治疗抽动障碍的疗效及对T细胞CD4/CD8比值的影响。方法将160例抽动障碍患者按治疗方案分为对照组(70例)和观察组(90例)。对照组给予氟哌啶醇治疗,观察组给予健脑止抽颗粒联合氟哌啶醇治疗。6个月疗程结束后,采用耶鲁综合抽动严重程度量表(YGTSS)评价疗效,比较两组临床疗效、复发率、行为心理问题发生情况、免疫功能指标及不良反应发生情况。结果对照组治疗总有效率和复发率分别为72.9%和31.4%,观察组分别为80.0%和17.8%,总有效率比较差异无统计学意义(P0.05),但观察组复发率低于对照组(P0.05)。治疗后,观察组存在多动注意障碍、攻击行为、睡眠障碍、精神紧张和脾气暴躁行为的患者例数少于对照组(P0.05),存在退缩行为的患者例数组间比较差异无统计学意义(P0.05)。观察组治疗后CD4/CD8比值明显高于对照组(P0.05)。治疗过程中,观察组不良反应发生率低于对照组(P0.05)。结论尽管健脑止抽颗粒辅助氟哌啶醇并不提高抽动障碍疗效,但可降低复发率,改善患者行为心理问题,增强免疫功能,且不良反应少,值得进一步研究。

Curative efficacy and impact on T lymphocyte of Jiannao Zhichou particles combined with haloperidol for tic disorders

Objective To investigate the curative efficacy and impact on CD4/CD8 ratio of T lymphocyte of Jiannao Zhichou par‐ticles combined with haloperidol for tic disorders .Methods A total of 160 cases of tic disorders were divided into control group (70 cases) and observation group (90 cases) .The control group was treated with haloperidol ,while the observation group was treated with Jiannao Zhichou particles combined with haloperidol .After six months ,Yale Global Tic Severity Scale (YGTSS) was applied to assess the curative efficacy .Curative efficacy ,recurrence rate ,occurrence of problems of behavior psychology ,immunological function and occurrence of adverse reactions were compared .Results Therapeutic efficiency rate and recurrence rate of control group were 72 .9% and 31 .4% ,and those of observation group were 80 .0% and 17 .8% .The total efficacy of the two groups were without significant difference(P>0 .05) ,while recurrence rate of observation group was lower than control group (P<0 .05) .After treatment ,cases with attention‐lacking ,aggressive behavior ,sleep disorder ,tensional emotion and irascibility in observation group were less than control group(P<0 .05) ,while cases with flinch behavior were without significant difference between the two groups (P>0 .05) .Ratio of CD4/CD8 in observation group was statistically higher than control group (P< 0 .05) .During treatment ,the occurrence of adverse reactions in observation group was statistically lower than control group (P<0 .05) .Conclusion Jiannao Zhi‐chou particles combined with haloperidol could significantly reduce recurrence rate ,improve problems of behavioral psychology and promote immunological function with fewer adverse reactions .