红细胞参数及铁指标鉴别慢性病贫血与慢性系统疾病性贫血的评价

目的了解贫血红细胞参数中红细胞平均体积(MCV)、平均红细胞血红蛋白量(MCH)、平均血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)和铁指标血清铁蛋白(SF)、血清铁(SI)、总铁结合力(TIBC)、未饱和铁结合力(UIBC)、铁饱和度(ISAT)对慢性病贫血(ACD)与慢性系统疾病性贫血鉴别诊断的临床价值。方法分别测定ACD组35例患者与慢性系统疾病性贫血组33例患者红细胞参数MCV、MCH、MCHC、RDW-CV和铁指标SF、SI、TIBC、UIBC、ISAT,两组比较采用非配对组间t检验,P0.05为差异有统计学意义。结果 ACD组与慢性系统疾病性贫血组比较,红细胞参数MCV、MCH显著减低(P0.05),RDW-CV显著增高(P0.05),MCHC差异无统计学意义(P0.05),铁指标SI、ISAT显著减低(P0.05),UIBC显著增高(P0.05),SF、TIBC差异无统计学意义(P0.05)。结论联合红细胞参数及铁指标对ACD与慢性系统疾病性贫血鉴别有一定的临床价值。

Evaluation of erythrocyte parameters and iron index for identifying chronic disease anemia and chronic systemic disease anemia

Objective To investigate the clinical values of erythrocyte parameters (MCV ,MCH ,MCHC and RDW‐CV) and iron indices of serum iron protein (SF) ,serum iron (SI) ,total iron binding capacity (TIBC) and unsaturated iron binding force (UIBC) , iron saturation (ISAT) in the differentiation diagnosis of anemia of chronic disease(ACD) and chronic systemic disease anemia . Methods MCV ,MCH ,MCHC ,RDW‐CV ,SF ,SI ,TIBC ,UIBC and ISAT were detected in 35 cases of chronic disease anemia (ACD group) and 35 cases of chronic diseases anemia group .The comparison between the two groups adopted the non‐paired inter‐group t test with P< 0 .05 as the statistical difference .Results The levels of MCV and MCH in the ACD group were significantly lower compared with the chronic systemic disease anemia group ,the RDW‐CV level was increased significantly ,while the MCHC level had no significant difference ,iron index SI and ISAT were significantly decreased ,UIBC was significantly increased ,while SF and TIBC had no significant difference .Conclusion The combination of erythrocyte parameters and iron indexes has a certain clinical value in the identification of chronic anemia and chronic systemic disease anemia .