长春市30405例体检人群血脂、血糖与尿酸异常及相关性分析

目的研究长春市18周岁以上30 405例体检人群高尿酸血症(HUA)检出率,探讨HUA与血脂、空腹血糖(FBG)的相关性。方法选取2015年1月至2015年6月在吉林大学第一医院检验科接受检查的30 405名18周岁以上体检者为研究对象,检测其血清三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HLD-C)、空腹血糖(FBG)及尿酸(UA)的水平。整理并分析各项指标异常检出率,并分析血脂、空腹血糖与HUA的关系。结果 30 405例体检人群中,高三酰甘油血症、高胆固醇血症、高低密度脂蛋白血症、低高密度脂蛋白血症、高血糖及HUA检出率分别为18.37%、7.7%、8.53%、10.64%、15.30%、24.41%。男性和女性HUA患病率分别为36.28%、12.42%,男性高于女性,差异有统计学意义(P0.05)。在男女性别分组后可见HUA组的TG、TC、LDL-C、FBG水平高于尿酸正常组,而HDL-C水平低于尿酸正常组,差异有统计学意义(P0.05)。多因素Logistic回归分析,男性、年龄、高TG、高LDL-C、低HDL-C、高FBG为HUA的危险因素。结论长春市18岁以上体检人群高血脂、高血糖、HUA患病率较高,尿酸升高与血脂、血糖代谢异常有一定相关性,合理膳食、加强运动并定期体检对预防此类疾病的发生具有重要意义。

Correlation of blood lipid,blood glucose and abnormal uric acid:a study of 30 405 cases received physical examination in Changchun

Objective To study the correlation of serum lipid ,fasting blood glucose (FBG ) and hyperuricaemia (HUA ) in 30 405 cases over 18 years old who received physical examination in Changchun city .Methods A total of 30 405 cases of physical examination population over 18 years old who accepted inspection from January 2015 to June 2015 in department of clinical labora‐tory were selected in the first affiliated hospital of Jilin university ,and level of serum triglyceride (TG) ,cholesterol (TC) ,low den‐sity lipoprotein (LDL‐C) ,high density lipoprotein (HDL‐C) ,FBG and uric acid (UA) were detected .The abnormal detection rate of each index ,and the relationship between blood lipid ,FBG and HUA were analyzed .Results Among the 30 405 subjects ,the rates of hypertriglyceridemia ,hypercholesterolemia hyperlipidemia ,hyper‐low‐density‐lipoprotein‐cholesterolmia ,hypo‐high‐density‐lipo‐protein‐cholesterolmia ,hyperglycemia and hyperuricemia were 18 .37% ,7 .7% ,8 .53% ,10 .64% ,15 .30% and 24 .41% ,respective‐ly .The prevalence of HUA in males (36 .28% ) was significantly higher than that of females (12 .42% )(P<0 .05) .TG ,TC ,LDL‐C and FBG levels in the HUA group were higher than that in the normal uric acid group ,while the level of HDL‐C was lower than that of the normal uric acid group ,the differences had statistic significance(P<0 .05) .Multiple Logistic regression analysis sugges‐ted that male ,age ,high TG ,high LDL‐C ,low HDL‐C and high FBG were risk factors for HUA .Conclusion The rates of hyper‐lipemia ,hyperglycemia and HUA of population over the 18 years old in Changchun are higher than that of other places ,UA level has certain correlation with abnormal metabolism of glucose and lipid .Balanced diet ,strengthening exercise and regular physical ex‐amination are important to prevent the occurrence of these diseases .