外周血中性粒细胞与淋巴细胞比值在非酒精性脂肪肝诊断中的应用

目的外周血中性粒细胞与淋巴细胞比值(NLR)在非酒精性脂肪肝(NAFLD)临床诊断中的价值。方法随机选取214例临床明确诊断为NAFLD且未经过药物治疗的患者作为NAFLD患者组,同时随机选取214例年龄及性别匹配的健康受试者作为健康对照组。两组研究对象均接受血常规检查并计算NLR,比较两组间NLR差异是否有统计学意义。结果 NAFLD患者组外周血平均NLR为(1.87±0.69),显著高于健康对照组的(1.66±0.26),差异有统计学意义(P0.05)。受试者工作特征曲线下面积为0.791,其95%置信区间为0.706~0.876,当cut off值取1.63时,敏感度为79.6%,1-特异性为69.0%,提示NAFLD可能存在肝损害。结论 NAFLD患者血清NLR明显高于健康人群,NLR对NAFLD的诊断有一定价值。

Application of peripheral blood neutrophil to lymphocyte ratio in diagnosis of nonalcoholic fatty liver disease

Objective To explore the value of peripheral blood neutrophil to lymphocyte ratio (NLR) in the diagnosis of nonal‐coholic fatty liver disease (NAFLD) .Methods Totally 214 patients with clinically definite diagnosis of NAFLD and without drug therapy were randomly selected as the experimental group ,and another 214 healthy subjects were randomly selected as control group .The two groups were received routine blood test and calculation of NLR ,NLR differences were compared between the two groups .Results The average NLR of peripheral blood in NAFLD patients was (1 .87 ± 0 .69) ,which was significantly higher than that in control group (1 .66 ± 0 .26) ,and the difference was statistically significant (P<0 .05) .The area under the ROC curve was 0 .791 ,95% CI:0 .706-0 .876 ,when the off cut value was 1 .63 ,the sensitivity was 79 .6% and the specificity was 69 .0% ,which suggested that NAFLD might had liver damage .Conclusion The serum NLR of NAFLD patients is significantly higher than that of healthy people ,and NLR have a certain value in the diagnosis of NAFLD .