正常妊娠妇女肾脏损伤指标检测

目的探讨肾脏损伤检测指标N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、尿微量清蛋白(mALB)、α_1微球蛋白(α_1-MG),β_2微球蛋白(β_2-MG)水平在正常妊娠妇女中的变化规律。方法将400例正常妊娠妇女纳入本研究,同时选取87例健康的入职体检护士作为对照组。所有纳入研究者留取晨尿先进行尿液常规检测,根据尿液常规检测结果分为尿糖阴性组、尿糖组和尿蛋白组,然后将所有尿液标本以1 500r/min离心5min,取上清液进行NAG、mALB、α_1-MG、β_2-MG检测。结果尿糖阴性组、尿糖组NAG、mALB、α_1-MG、β_2-MG均高于对照组(P0.05),尿糖组上述4项指标均高于尿糖阴性组(P0.05);蛋白20、30组上述4项指标均高于对照组(P0.05);晚期妊娠组上述4项指标均高于对照组(P0.05)。结论尿液常规检查尿糖、尿蛋白阴性的孕妇,肾脏损伤指标NAG、mALB、α_1-MG、β_2-MG水平较低,随着尿糖、尿蛋白的增多,指标相应升高;晚期妊娠较早、中期妊娠者肾脏损伤程度更严重。

Detection of renal injury in normal pregnant women

Objective To investigate the level change of renal injury indicators including N‐acetyl‐beta‐D‐glucosaminidase (NAG) ,microalbumin(mALB) ,α1‐microglobulin(α1‐MG) andβ2‐microglobulin(β2‐MG) in normal pregnant women .Methods 400 normal pregnant women were enrolled in the study ,and 87 healthy nurses were enrolled as the control group .According to urine routine test results of the experimental group ,the 400 pregnant momen were divided into urine‐glucose negative group ,urine‐glu‐cose and urine‐protein group .Morning urine samples were collected from all the groups for routine urine urinalysis .Then those sam‐ples underwent 1 500 r/min centrifugation for 5 min ,and the supernatant was tested for NAG ,mALB ,α1‐MG ,β2‐MG .Results The concentrations of NAG ,mALB ,α1‐MG and β2‐MG in urine‐glucose negative group and urine glucose group were higher than the control group(P<0 .05) .The levels of the four indicators in urine‐glucose group were higher than the urine‐glucose negative group (P<0 .05) .The levels of the four indicators in protein 20 and 30 groups were higher than the control group(P<0 .05) .NAG , mALB ,α1‐MG ,β2‐MG concentrations in late pregnancy group were higher than the control gorup(P<0 .05) .Conclusion The renal injury indicators NAG ,mALB ,α1‐MG andβ2‐MG were lower in the urine‐glucose and urine‐protein negative specimen ,as the urine glucose and urine protein increased ,the concentrations of indicators increased .The impairment of kidney is more serious in late pregnancy than in early and mid pregnancy .