219例地高辛血药浓度监测结果及不良反应分析

目的：对本院2015年1～9月地高辛血药浓度监测结果进行回顾性分析，为临床合理用药提供参考。方法采用全自动免疫分析仪对219例口服地高辛患者进行血药浓度的检测，并对监测结果及药品不良反应（ADR ）进行统计、分析。结果地高辛血药浓度在0．5‐2．0ng／mL有153例（1．03±0．31ng／mL），发生7例不良反应；＜0．5ng／mL有30例（0．3±0．13ng／mL）；＞2．0 ng／mL有36例（3．06±0．78 ng／mL），共9例不良反应。结论及时有效的监测地高辛血药浓度，实行个体化治疗，降低不良反应发生率。

Results of serum drug concentration of Digoxin and adverse reactions analysis

Objective To summarize the results of serum drug concentration of digoxin in the hospital for clinical rational use . Methods Serum concentration of digoxin(219 cases)was determined by access immunoassay system and the results were statisti‐cally analyzed .Results there were 7 cases drug adverse reactions(ADR)with the serum drug concentration in the therapeutic win‐dow (0 .5‐2ng/mL) ,meanwhile ,9 cases ADR with the serum drug concentration higher than the maximun effective concentration (>2 .0ng/mL) .Conclusion Timely and effective monitoring of digoxin serum concentration should be established ,to individualize the treatment programs ,ensure the efficacy and reduce the occurrence of adverse reactions .