血清癌胚抗原与溶血磷脂酸联合检测在非小细胞肺癌诊断中的应用价值

目的探讨血清癌胚抗原(CEA)与溶血磷脂酸(LPA)联合检测在非小细胞肺癌诊断中的应用价值。方法选取2013年1月至2015年6月该院收治的85例非小细胞肺癌患者作为非小细胞肺癌组。另外,选取同期80例肺炎患者作为肺炎组,以及80例健康体检者作为健康对照组。分别采用酶联免疫吸附法和免疫发光法测定上述人群的血清LPA和CEA水平。比较不同组间人群血清CEA与LPA水平,不同病理类型的非小细胞肺癌患者血清指标阳性率,以及CEA和LPA单独及联合检测用于非小细胞肺癌诊断的效能。结果非小细胞肺癌组患者血清CEA、LPA水平[(23.5±17.2)ng/mL、(9.8±2.4)μmol/L]高于肺炎组患者[(2.8±1.1)ng/mL、(1.8±0.4)μmol/L]和健康对照组患者[(2.3±0.8)ng/mL、(1.6±0.4)μmol/L],差异有统计学意义(P0.05);腺癌组患者血清CEA阳性检测率(68.3%)显著高于鳞状细胞癌组(32.4%)和组织未分型组患者(40.4%),差异有统计学意义(P0.05);血清CEA与LPA联合检测的准确度(69.4%)和灵敏度(61.2%)高于CEA、LPA单独检测的准确度、灵敏度;联合检测的特异度(73.8%)低于CEA、LPA单独检测的特异度(77.5%、75.6%)。结论血清CEA与LPA联合检测有利于提高非小细胞肺癌诊断率,值得临床推广应用。

The value of serum carcinoembryonic antigen combined with lysophosphatidic acid detection in the diagnosis of non-small cell lung cancer

Objective To investigate the value of serum carcinoembryonic antigen(CEA) combined with lysophosphatidic acid (LPA) detection in the diagnosis of non‐small cell lung cancer .Methods From January 2013 to June 2015 ,85 cases of non‐small cell lung cancer patients in the hospital were enrolled in the study as non‐small cell lung cancer group .In addition to that ,80 cases of patients with pneumonia and 80 cases of healthy people were recruited as pneumonia and control group respectively .LPA and CEA concentrations of those people were determined by using enzyme‐linked immunosorbent assay and immunoluminescence meth‐od .Serum CEA and LPD concentrations among different groups and positive rate of serum markers among patients with non small cell lung cancer of different pathological types were compared .Efficacies of single and combined detection of CEA and LPA in the diagnosis of non small cell lung cancer were also compared .Results Serum CEA and LPA concentrations of patients with non‐small cell lung cancer were (23 .5 ± 17 .2)ng/mL and (9 .8 ± 2 .4)μmol/L respectively ,which were both significantly higher than pneumo‐nia group[(2 .8 ± 1 .1)ng/mL and (1 .8 ± 0 .4)μmol/L] and control group[(2 .3 ± 0 .8)ng/mL and (1 .6 ± 0 .4)μmol/L)] ,and the difference was statistically significant(P< 0 .05) .Serum CEA positive rate of adenocarcinoma cancer patients(68 .3% ) was signifi‐cantly higher than patients with squamous cell carcinoma(32 .4% ) and no tissue type (40 .4% ) ,the difference was statistically sig‐nificant(P< 0 .05) .Detection accuracy(69 .4% ) and sensitivity(61 .2% ) of serum carcinoembryonic antigen combined with lyso‐phosphatidic acid was higher than the single detection while specificity (73 .8% ) was less than single detection of CEA and LPA (77 .5% and 75 .6% ) .Conclusion Serum carcinoembryonic antigen combined with lysophosphatidic acid detection help to improve the rate of non‐small cell lung cancer ,and it was worthy of clinical application .