探讨丙肝核心抗原检测在母婴传播中的应用价值

目的：探讨丙肝核心抗原检测在母婴传播中的应用价值。方法选取选取2014年1月～2015年1月在我院就诊的HCV‐Ab（ELISA）阳性产妇100例作为研究对象，产妇于生产前采集静脉血3～5 mL ，新生儿采集脐血2～3 mL 进行检测。首先使用HCV‐RNA 对100例HCV‐Ab（IGg）阳性产妇血清标本进行检测。使用HCV‐cAg、HCV‐Ab、HCVRNA三种方法对新生儿脐血标本进行检测，观察三种方法的阳性率。结果 HCVcAg阳性率与 HCV‐Ab（IgG）的阳性率比较差异具有统计学意义，P＜0．05。HCVcAg阳性率与HCV‐RNA阳性率比较，差异没有统计学意，P＞0．05。结论 HCVcAg检测在HCV母婴传播初期诊断中，可作为临床诊治的依据，值得基层医院推广。

Application value of detection of HCV core antigen in maternal-neonatal transmission

Objective To study the application value of detection of HCV core antigen in maternal‐neonatal transmissio .Methods 100 puerperants with positive HCV‐Ab(ELISA)from January 2014 to January 2015 in our hospital were selected as objects .3‐5 mL of venous blood of puerperants was collected to detected and 2‐3 mL of mbilical cord blood of newborns was collected to detected . 100 maternal serum samples were detected by HCV‐RNA and Serum samples of newbown were detected by HCV‐cAg、HCV‐Ab、HCVRNA .The positive rate of three methods were observed .Results There was a significant difference between positive rate of HCVcAg and HCV‐Ab(IgG)(P<0 .05).There was no statistically significant difference between positive rate of HCVcAg and HCV‐RNA(P>0 .05) .Conclusion HCVcAg detection in the early diagnosis of maternal‐neonatal transmission of HCV can be used as the basis for clinical diagnosis and treatment ,is worthy of promotion in primary hospital .