乳腺癌组织中GATA3的表达及其在乳腺癌发生中的意义

目的分析乳腺癌组织中GATA3的表达及其在乳腺癌发生中的意义。方法选择122例乳腺癌组织为研究组,另外选取良性乳腺肿瘤组织切除后边缘正常组织40例为对照组,采用免疫组织化学法检测正常乳腺组织、乳腺癌组织GATA3表达,并分析GATA3表达与乳腺癌临床病理特征之间的关系。结果乳腺正常组织和乳腺癌组织均有GATA3表达。乳腺正常组织阳性表达率(80.0%)高于乳腺癌组织(59.8%),有淋巴结转移患者GATA3阳性表达率(35.3%)低于无淋巴结转移患者(77.5%),雌激素受体阳性(ER)患者GATA3阳性表达率(76.5%)高于ER阴性者(47.9%),孕激素阳性(PR)患者GATA3阳性表达率(73.2%)高于PR阴性患者(53.1%),差异有统计学意义(P0.05)。中危组患者GATA3阳性表达率(67.1%)高于高危组(47.8%),差异均有统计学意义(P0.05)。结论乳腺癌组织GATA3表达下调,GATA3表达异常与乳腺癌发生、发展、预后有关。

The clinical significance of expression of GATA 3 in the patients with breast cancer

Objective To analyze the clinical significance of expression level of GATA3 in the patients with breast cancer .Meth‐ods GATA3 level was detected by immunohistochemistry in the tissue of 122 patients with breast cancer and 40 healthy people . And the relationship of expression of GATA3 and clinical pathological features was analyzed .Results The expression of GATA3 was found both in the breast cancer tissue and normal breast tissue .The positive rate of GATA3 in normal breast tissue (80 .0% ) was significantly higher in that of in breast cancer tissue (59 .8% ) (P<0 .05) .The positive rate in the patients with lymphonodes metastases (35 .3% ) was found to be significantly lower than that in the patients without metastases (77 .5% ) (P<0 .05) .And the positive rate in patients with estrogen receptor (ER) positive breast cancer (76 .5% ) was significantly higher than that in patients with ER negative breast cancer (47 .9% ) (P<0 .05) .And the positive rate in patients with progesterone receptor (PR) positive breast cancer (76 .5% ) was significantly higher than that in patients with PR negative breast cancer (47 .9% ) (P<0 .05) .In addi‐tion ,the positive rate in patients with moderate recurrent risk (67 .1% ) was higher than that in patients with high recurrent risk (47 .8% ) (P<0 .05) .Conclusion The expression of GATA3 in the breast cancer tissue is down‐regulated ,which may be correla‐ted with the occurrence ,development and prognosis of breast cancer .