炎症性肠病患者凝血指标变化及其临床意义研究

目的探讨炎症性肠病(IBD)患者凝血指标的变化,及其与疾病活动程度的关系。方法回顾性分析2012年3月至2015年3月就诊的67例IBD患者及50例健康者血小板计数(PLT)、血小板平均体积(MPV)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)等指标检测结果,比较患者与健康者的差异,不同病情程度患者之间的差异,以及各指标与疾病活动指数的相关性。结果与健康者相比,IBD患者PLT、PT和FIB升高,MPV下降;不同病情严重程度溃疡性结肠炎患者间PLT、MPV、PT和FIB水平比较差异有统计学意义(P0.05),不同病情严重程度克罗恩病患者间PLT、MPV和FIB水平比较差异有统计学意义(P0.05);PLT和FIB与IBD疾病活动指数呈正相关,MPV与疾病活动指数呈负相关。结论 IBD患者体内凝血功能异常,表现为PLT升高、MPV下降,PT延长及FIB升高,PLT、MPV和FIB或可作为判断IBD疾病活动性的指标。

Clinical significance of coagulation function in inflammatory bowel disease

Objective To analyze the changes of coagulation function in inflammatory bowel disease(IBD) patients ,and investi-gate the relationship between the related indexes of blood coagulation function and the activity of the disease .Methods From March 2012 to March 2015 ,platelet counts (PLT ) ,mean platelet volume(MPV) ,thrombin time(TT) ,prothrombin time(PT ) ,acti-vated partial thromboplastin time(APTT ) and fibrinogen(FIB) of 67 cases of IBD patients and 50 healthy subjects were detected and compared .The relationship between the coagulation parameters and disease activity index were also analyzed .Results PLT , PT ,and FIB were higher in IBD group ,while M PV was lower ,compared with healthy subjects(P< 0 .05) .In IBD patients ,PLT and FIB were positively ,and MPV was negatively correlated with disease activity index(P< 0 .05) .Conclusion The function of blood coagulation might be abnormal in IBD patients ,manifested as elevated PLT ,decreased MPV ,prolonged PT and increased FIB . PLT ,MPV and FIB could be used to assess disease activity of IBD .