急性肾损伤患者NT-proBNP与血管外肺水指数相关性研究

目的探讨接受机械通气治疗的急性肾损伤(AKI)患者血浆N末端B型钠尿肽前体(NT-proBNP)水平动态变化与血管外肺水指数(EVLWI)的相关性。方法将80例接受机械通气及连续性肾脏替代治疗(CRRT)的AKI患者分为A、B、C组,各组血清肌酐(SCr)水平依次升高、尿量依次降低。分别在CRRT治疗前及治疗后12、24、72h检测血浆NT-proBNP、SCr水平及EVLWI的水平,分析其间相关性。结果各组患者治疗前APACHEⅡ评分、SCr水平比较差异有统计学意义(P0.05)。SCr、NT-proBNP、EVLWI水平随CRRT治疗时间延长呈下降趋势。各组患者CRRT治疗后72h上述指标检测结果与治疗前比较差异有统计学意义(P0.05),各组间相同时间点各指标检测结果比较差异有统计学意义(P0.05)。各组患者CRRT治疗前及治疗后12、24、72h血浆NT-proBNP水平与SCr、EVLWI呈正相关(P0.05)。结论 AKI患者血浆NT-proBNP水平与EVLWI具有良好的相关性。

Association between plasma NT-proBNP and extravascular lung water index in patients with acute kidney injury

Objective To discuss correlation between plasma N‐terminal B‐type atriuretic peptide precursor (NT‐proBNP) and extravascular lung water index (EVLWI) in patients with acute kidney injury (AKI) received mechanical ventilation .Methods A to‐tal of 80 AKI patients receiving mechanical ventilation and continuous renal replacement therapy (CRRT ) were divided into A ,B and C group ,of which serum creatinine(SCr) level gradually inreased and urinve volume decreased .Plasma NT‐proBNP ,SCr and EVL‐WI were detected before and 12 ,24 ,72 h after CRRT .Results APACHEⅡ score and SCr level were significantly different between all groups (P<0 .05) .SCr ,NT‐proBNP and EVLWI levels gradually decreased aftar CRRT ,values of which ,detected 72 h after CRRT ,were lower than values detected before CRRT (P<0 .05) .The difference between the groups was statistically significant at the same period(P<0 .05) .Before and 12 ,24 ,72 h after CRRT ,plasma NT‐proBNP were positively correlated with SCr and EVL‐WI(P<0 .05) .Conclusion Plasma NT‐proBNP and EVLWI might have correlation in AKI patients .