苦参碱治疗对慢性病毒性肝炎患者血流参数影响的检验分析

目的探讨苦参碱治疗对慢性病毒性肝炎患者血流参数的影响,以期提高疗效。方法选取2013年2月至2016年2月176例慢性病毒性肝炎患者为研究对象,分成2组,每组88例,均予丹参注射液加入氯化钠注射液静脉滴注,持续8周,对照组加用甘草酸二铵注射液加入0.9%氯化钠注射液静脉滴注,观察组则加用苦参碱加入氯化钠注射液静脉滴注,均持续8周,观察治疗前后门脉最大血流速度(MFV)、门脉血流量(FV)、门静脉内径(D)Z值及丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBiL)变化情况。结果对照组显效率34.09%、总有效率79.55%,观察组显效率46.59%、总有效率90.91%,两组在显效率和总有效率上比较差异有统计学意义(P0.05)。对照组轻度、中度、重度患者的MFV、FV、D治疗前后比较差异无统计学意义(P0.05),观察组轻度、中度、重度患者的MFV、FV、D治疗前后比较差异有统计学意义(P0.05),观察组治疗后的患者轻度、中度、重度MFV、FV、D的比较差异有统计学意义(P0.05);两组治疗后在ALT、AST、TBiL较治疗前均明显下降,治疗前后比较差异有统计学意义(P0.05),观察组治疗后在ALT、AST、TBiL水平均低于对照组,差异有统计学意义(P0.05)。结论苦参碱对慢性病毒性肝炎血流参数有促进作用,是治疗慢性病毒性肝炎有效药物。

Effect of matrine treatment on the blood flow parameters of patients with chronic liver disease

Objective To study the effect of matrine treatment on the blood flow parameters of patients with chronic liver dis‐ease and to improve the curative effect .Methods Totally 176 cases with chronic liver disease were selected from December 2013 to January 2016 as the research subjects ,which were divided into the study group and control group ,88 cases in each group .All the subjects were given the intravenous drip of salvia miltiorrhiza injection adding to sodium chloride injection for 8 weeks .And control group was given intravenous drip of diammonium glycyrrhetate injection adding to sodium chloride injection ,while observation group was given intravenous drip of matrine adding to sodium chloride injection ,both the two group were observed for 8 weeks . And the changes of portal vein maximum blood flow velocity (MFV) ,blood flow volume (FV) ,inner diameter of portal vein (D) as well alanine aminotransferase (ALT) ,aspartate aminotransferase (AST) as well as total bilirubin (TBiL) were observed before and treatment .Results The efficiency and total effective rate of control group were 34 .09% and 79 .55% ,respectively ,which of the study group were 46 .59% and 90 .91% ,respectively .The differences between the two groups had statistical significance(P<0 .05) .And the differences of MFV ,FV and D in control group before and after treatment had no statistical significance(P>0 .05) . Differences of MFV ,FV and D of control group in patients with mild ,moderate and severe chronic liver disease had no statistical differences(P>0 .05) ,while which of the observation group had statistical significant difference before and after treatment(P<0 .05) ,and the differences of observation group after treatment in patients with mild ,moderate and severe chronic liver disease were statistically significant(P< 0 .05) .ALT ,AST and TBiL of the two groups after treatment were significantly lower than before treatment (P<0 .05) ,in addition ,ALT ,AST and TBiL of the observation group after treatment were significantly lower than that of the control group(P<0 .05) .Conclusion Matrine improves blood flow parameters of chronic liver disease ,which is the effective drug for the treatment of chronic hepatitis .