肺癌患者PCDH20、VEGF蛋白及其与临床病理指标的关系

目的研究肺癌患者原钙黏蛋白-20(PCDH20)、血管内皮生长因子(VEGF)蛋白的变化及其与临床病理指标的关系。方法收集2013年8月至2015年7月行手术切除的原发性肺癌组织标本60例,取出10例肺癌周边相对较为正常的肺组织视为对照组。观察肺癌组和对照组的PCDH20、VEGF阳性表达情况。对肺癌组织中PCDH20、VEGF蛋白的阳性表达和年龄、性别、病变部位、临床分期、分化程度及淋巴结转移之间的关系进行分析。结果肺癌组中的PCDH20、VEGF阳性率显著高于对照组,差异均有统计学意义(P0.05)。肺癌组织中的PCDH20、VEGF蛋白的表达和临床分期、是否存在淋巴结转移有着密切的关联性(P0.05),但和患者的年龄、性别及病变部位无相关性(P0.05)。多因素Logistic回归显示,临床分期、淋巴结转移均是影响PCDH20、VEGF蛋白表达的因素(P0.05)。结论临床分期、淋巴结转移病理因素和肺癌PCDH20、VEGF蛋白的表达存在密切关联性。

Correlation of PCDH20,VEGF protein and clinical pathological indicators in patients with lung cancer

Objective To study the correlation of protocadherin‐20 (PCDH20) ,vascular endothelial growth factor (VEGF) pro‐tein and clinical pathological indicators in patients with lung cancer .Methods A total of 60 cancer tissue samples were collected as research group by surgical resection from August 2013 to July 2015 ,and 10 healthy lung tissue samples were selected as control group .Expression of PCDH20 and VEGF were detected and compared between the two groups .The correlation of level of PC‐DH20 ,VEGF protein ,age ,gender ,lesion site ,clinical stage ,differentiation degree and lymph node metastasis were analyzed .Results The positive rates of PCDH20 and VEGF in research group were significantly higher than the control group (P< 0 .05) .The ex‐pression of PCDH20 and VEGF protein were correlated with clinical stage ,and lymph node metastasis (P < 0 .05) .While the ex‐pression of PCDH20 and VEGF protein were not correlated with the patients′ age ,sex and lesion sites (P> 0 .05) .Multiple Logistic regression analysis showed that clinical stage ,and lymph node metastasis were the factors affecting the expression of PCDH 20 and VEGF (P< 0 .05) .Conclusion Clinical stage ,and lymph node metastasis have a closed correlation with the expression of PCDH 20 and VEGF protein .