益肾活血方配合激素和环磷酰胺治疗狼疮肾炎的临床观察

目的观察益肾活血方治疗狼疮肾炎(LN)的临床疗效。方法将60例狼疮肾炎患者随机分为2组。对照组30例予激素和环磷酰胺;治疗组30例在对照组治疗基础上加用益肾活血方,每日1剂,水煎分2次服。2组均1个月为1个疗程,3个疗程后观察治疗前后LN的活动指标(发热、皮疹、关节痛、脱发),尿蛋白,血尿,肾功能,肝功能,血清抗双链DNA(ds-DNA)滴度,补体C3、C4等变化情况。结果治疗组总有效率93.3%,对照组总有效率80.0%,2组比较差异有统计学意义(P<0.05);2组治疗后24h尿蛋白、血清白蛋白、血肌酐、尿素氮、丙氨酸氨基转移酶、抗ds-DNA抗体滴度及C3、C4与本组治疗前比较差异均有统计学意义(P<0.05,P<0.01),2组治疗后比较差异均有统计学意义(P<0.05),治疗组均优于对照组;2组不良反应发生率和复发率比较差异均有统计学意义(P<0.05),治疗组低于对照组。结论益肾活血方治疗狼疮肾炎疗效确切,并可降低西药副作用,减少并发症,降低复发率。

Clinical observation on therapeutic effect of Yishenhuoxue decoction integrated with western medicine on lupus nephritis

Objective To observe the therapeutic effect of Yishenhuoxue decoction combined with western medicine on lupus nephritis.Methods 60 patients with lupus nephritis(LN)were randomly divided into two groups.30 patients in control group were treated by hormones and cyclophosphamide;The other 30 patients in treatment group were treated similarly plus Yiqihuoxue decoction.The activity parameters of LN,urinary protein,liver function,serum anti-ds-DNA,complete C3,C4 were evaluated in both groups before and after the treatment.Results The total effective rate in treatment group was 93.3%,which was 80% in control group,there was a significant difference between two groups(P<0.05);there were significant differences in urinary protein,liver function,serum anti-ds-DNA,complete C3,C4 in both groups before and after the treatment(P<0.05 or P<0.01);after the treatment there was a significant difference in these parameters between treatment group and control group(P<0.05),and those in treatment group were superior to those of control group;there were significant differences in the incidence of adverse reaction and recurrence after treatment between two groups(P<0.05),and those in treatment group was lower than those in control group.Conclusion Yiqihuoxue decoction is effective in treating lupus nephritis,which can reduce the side effects of western medicines and decrease complications and recurrent rate.