| 慢传输型便秘结肠肌间丛NOS、SOM、5-HT免疫反应性变化 |
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| 引用本文： | 童卫东,张胜本,张连阳,黄显凯. 慢传输型便秘结肠肌间丛NOS、SOM、5-HT免疫反应性变化[J]. 中华胃肠外科杂志, 1999, 2(3): 5 |
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| 作者姓名： | 童卫东 张胜本 张连阳 黄显凯 |
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| 作者单位： | 400042,重庆,第三军医大学大坪医院野战外科研究所普外科 |
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| 基金项目： | 中青年科技专家基金!资助项目（960134） |
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| 摘 要： | 目的 探讨一氧化氮（ＮＯ） 、生长抑素（ＳＯＭ）及５羟色胺（５ＨＴ） 在慢传输型便秘（ＳＴＣ） 发病中的作用。方法 用免疫组织化学法结合计算机辅助的图像分析技术检测１５ 例ＳＴＣ 患者乙状结肠肌间丛一氧化氮合酶（ＮＯＳ） 、ＳＯＭ 及５ＨＴ的免疫反应性变化。结果 与对照组相比，ＳＴＣ 患者乙状结肠肌间丛ＮＯＳ、５ＨＴ免疫反应性增强（ Ｐ＜ ０－０１ ，Ｐ＜ ０－０５） ，而ＳＯＭ 无显著差别（ Ｐ＞ ０－０５）。结论 ＮＯＳ及５ＨＴ 免疫反应性增强是ＳＴＣ 患者结肠传输减慢的神经病理基础，ＳＯＭ 在ＳＴＣ结肠动力减弱中的作用不明显。
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| 关 键 词： | 便秘 肌间神经丛 一氧化氮 生长抑素 5-羟色胺 |
Change of NOS, SOM and 5-HT immunoreactivity in myenteric plexus of sigmoid colon of patients with slow transit constipation |
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| TONG Weidong, ZHANG Shengben,ZHANG Lianyang,et al.. Change of NOS, SOM and 5-HT immunoreactivity in myenteric plexus of sigmoid colon of patients with slow transit constipation[J]. Chinese journal of gastrointestinal surgery, 1999, 2(3): 5 |
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| Authors: | TONG Weidong ZHANG Shengben ZHANG Lianyang et al. |
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| Affiliation: | TONG Weidong, ZHANG Shengben,ZHANG Lianyang, et al. Department of General Surgery, Daping Hospital, Third MilitaryMedical University, Chongqing 400042 |
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| Abstract: | Objective To explore the role of nitric oxide(NO), somatostatin (SOM) and 5 hydroxytryptamine (5 HT) in pathogenesis of slow transit constipation (STC). Methods By using immunohistochemistry and computer assistant image analysis system, NOS, SOM and 5 HT immunoreactivity were examined in myenteric plexus of sigmoid colon resected from 15 patients with STC. Results Comparison with the controls, the immunoreactivity of NOS and 5 HT was increased significantly at myenteric plexus of STC, and no significant difference was determined in SOM. Conclusion The increase of immunoreactivity of NOS and 5 HT is the physiopathology basis of STC, and SOM has no obvious effect on the slow colonic transit. |
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| Keywords: | Constipation Myenteric plexus Nitric oxide Somatostatin 5 hydroxytryptamine |
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