孤立性脑转移瘤CT灌注成像与VEGF表达对照研究

目的运用多层螺旋CT(MSCT)灌注成像的方法获取脑肿瘤组织的表面通透性(permeabilitysurface,PS)值,探讨PS值所描述的孤立性脑转移瘤血管通透性与血管内皮生长因子(VEGF)表达的空间分布相关性。方法21例孤立性脑转移患者于术前行多层螺旋CT灌注检查,计算并分析其CT灌注图像和PS值,测定标本VEGF表达。结果肿瘤强化呈环形16例,结节状5例。在环形强化中肿瘤边缘呈高PS值15例,边缘VEGF高表达13例;在结节状强化中边缘与中心区均表现为高PS值,边缘及中心区VEGF均高表达为5例。结论孤立性脑转移瘤组织的VEGF表达与PS值间具有显著的相关性(P<0.01),多层螺旋CT灌注成像可以用于脑转移瘤血管生成调控的监测。

Correlation of CT Perfusion Imaging with VEGF Expression in Solitary Brain Metastases

Objective:Using multi-slice helical CT perfusion imaging to obtain PS (permeability surface) value so as to evaluate the correlation between PS value and vascular endothelial growth factor (VEGF) expression in solitary brain metastases.Methods:Multi-slice helical CT perfusion imaging was performed in sixteen patients with solitary brain metastases.PS values were calculated from the central and peripheral parts of tumors respectively.The VEGF expression in tumors and peripheral tissues were determined by immunohistochemistry staining.Results:Rim enhancement was found in 16 cases,while nodular enhancement was found in 5 cases,respectively.In the rim enhancement cases,the border of the tumor had higher PS value;the VEGF expression of the border was high in 13 cases.In the nodular enhancement cases,the border and the central part had a high permeability;the VEGF expression was high in both the border and central parts in 5 cases.It was highly significant (P<0.01) that the high VEGF expression part in the tumors had a high PS value.Conclusion:The VEGF expression of brain metastases has a positive correlation with PS value in CT perfusion imaging.CT perfusion imaging can be used in the surveillance of angiogenesis activity of brain metastases.