| nm23-H_1mRNA表达与肾母细胞瘤临床行为的关系 |
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| 引用本文： | 步星耀,金百祥,叶颖江,王德辉,王恩敏.nm23-H_1mRNA表达与肾母细胞瘤临床行为的关系[J].中国肿瘤临床,1997(3). |
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| 作者姓名： | 步星耀 金百祥 叶颖江 王德辉 王恩敏 |
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| 作者单位： | 上海医科大学儿科医院处科!上海市，200032，上海医科大学儿科医院处科!上海市，200032，上海医科大学，上海医科大学，上海医科大学 |
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| 摘 要： | 应用Northernblot分子杂交技术，检测30例肾母细胞瘤及其对应正常肾组织中nm23－H1mRNA表达。通过nm23－H1mRNA水平的比较及其与临床病理的分析，发现肾母细胞瘤nm23－H1mRNA呈低表达，随着病程的演进和转移的出现，肿瘤细胞中nm23－H1mRNA表达水平呈显著性降低，与肿瘤的病理类型无显著相关性（P＞0．05）。提示nm23－H1RNA低表达可能是肾母细胞瘤演进和转移的重要因素。
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| 关 键 词： | nm23-H_1mRNA 肾母细胞瘤 肿瘤转移 |
Correlation between nm23-H_1 mRNA and the Clinical Behavior of Nephroblastoma |
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| Bu Xing-Yao, Jin Bai-Xiang, Ye Ying-Jiang et al.Correlation between nm23-H_1 mRNA and the Clinical Behavior of Nephroblastoma[J].Chinese Journal of Clinical Oncology,1997(3). |
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| Authors: | Bu Xing-Yao Jin Bai-Xiang Ye Ying-Jiang |
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| Abstract: | The mRNA expression of nm23-H1 gene was examined with Northern blot hybridization in resected nephroblastomas and their corresponding normalkidney tissues from 30 patients. Further statistical investigation showed that nm23-H1 gene expression was at low level in nephroblastomas. The average level of nm23-H1 gene expression was significantly decreased with the progression and metastasis of tumors. There was no correlation between reduced expression of nm23-H1 gene and pathologic types of nephroblastoma. The result suggested that reduced expression of nm23-H1 gene might play an important role in the tumor progression and metastasis. |
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| Keywords: | nm23-H_1 gene mRNA Nephroblastoma Tumor Metastasis |
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