高原扁桃体反复感染伴OSAHS患者血中CRP、TNF-a的相关性研究

目的：观察高原（2300m～3700m）扁桃体反复感染伴阻塞性睡眠呼吸暂停低通气综合征（OSABS）患者血中C-反应蛋白（CaP）、肿瘤细胞坏死因子-a（TNF—a）水平影响。方法：选择通过多导睡眠仪（PSC）确诊的30例OSAHS患者和29例正常对照组。用放射免疫法测定两组血清TNF-a水平，用散射比浊法测定两组血清CRP水平，进行对照分析。结果：OSAHS患者呼吸暂停-低通气指数（AHI）与CRP、TNF—a水平呈正相关（r=0．37，P〈0．01），与夜间最低SaO2呈负相关（r=-0．56，P〈0．001）。OSAHS患者CRP、TNF—a水平较对照组显著性增高（P〈0．001）。结论：OSAHS患者CRP、TNF—a血清水平增高与炎症、低氧血症的发生相关。

Serum Levels of CRP and TNF-a in Obstructive Sleep Apnea Hypoventilation Syndrome Patients with Chronic Tonsillitis at High Altitude

Objective: To observe changes of CRP and TNF-a levels in obstructive sleep apnea hypoventilation syndrome (OSAHS) patients with chronic tonsillitis at high altitude (2 300m~3 700m). Methods: 30 cases with OSAHS diagnosed by PSG and 29 healthy adults (as a control group) were selected. The level of the serum TNF-a was detected by radioimmunoassay. The level of the serum CRP was detected by immune scatter turbidimetry methods. Results: AHI of the OSAHS had a positive correlation with CRP and TNF-a (r=0.37,P<0.01) and a negative correlation with night lowest SaO2 (r=-0.56,P<0.001). There were significantly differences in the levels of the CRP and TNF-a between OSAHS patients and control groups (P<0.001). Conclusions: The increase of the CRP and TNF-a levels in OSAHS patients with chronic tonsillitis associated with condition of inflammation and hypoxia.