| HPLC法测定新肤螨灵软膏中甲硝唑的含量 |
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| 引用本文： | 景巧敏,吴随凤,李栋. HPLC法测定新肤螨灵软膏中甲硝唑的含量[J]. 齐鲁药事, 2005, 24(11): 667-668 |
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| 作者姓名： | 景巧敏 吴随凤 李栋 |
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| 作者单位： | 1. 山东健康药业有限公司,济南,250022
2. 济南市药品检验所,济南,250001 |
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| 摘 要： | 目的采用高效液相色谱法测定新肤螨灵软膏甲硝唑含量。方法色谱柱为Diamonsil-C18柱(250mm×4.6mm,5μm),甲醇-水(20∶80)为流动相,流速为1.0ml.min-1,检测波长为315nm。结果线性范围为7.614~38.07μg.ml-1(r=0.9996),甲硝唑的平均回收率为100.3%,RSD为0.66%。结论该法简便、灵敏、准确。
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| 关 键 词： | 高效液相色谱法 新肤螨灵软膏 甲硝唑 |
| 文章编号： | 1672-7738(2005)11-0667-02 |
Determination of the metronidazole in Xinfu Manling Ointment by HPLC |
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| Jing Qiao-min,Wu Sui-feng,Li Dong. Determination of the metronidazole in Xinfu Manling Ointment by HPLC[J]. qilu pharmaceutical affairs, 2005, 24(11): 667-668 |
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| Authors: | Jing Qiao-min Wu Sui-feng Li Dong |
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| Affiliation: | Jing Qiao-min,Wu Sui-feng,Li Dong~1 |
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| Abstract: | Objective The metronidazole in Xinfu Manling ointment was determined by HPLC.Methods Diamonsil-C_(18) column(250mm×4.6mm,5μm)was used,the mobile phase was methanol-water(20∶80),flow rate was 1.0ml·min~(-1),and detective wavelength was at 315 nm.Results The linear range was 7.614～38.07μg·ml~(-1)(r=0.9996),the average recovery rate was 100.3%,and RSD was 0.66%.Conclusion This method was convenient,sensitive and accurate. |
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| Keywords: | HPLC Xinfu Manling ointment metronidazole |
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