慢性腹泻患者1185例感染人芽囊原虫的临床分析

目的 了解慢性腹泻患者人芽囊原虫感染和患病情况的临床特点,并分析其原因,为采取相应的防治措施提供科学依据.方法 对在我院2011年1月～ 2011年12月就诊的1185例慢性腹泻患者进行粪便检查,并对人芽囊原虫阳性患者的感染情况与实验室检测结果进行调查分析.结果 受检患者人芽囊原虫感染率为12.24％,其中有粘液脓血便的感染率明显高于其他类型腹泻者(P＜0.01);不同性别、年龄间感染率差异无统计学意义(P＞0.05);农民感染率最高(20.29％).实验室辅助检查中,69.66％感染患者中有血红蛋白降低,80.69％感染患者IgG、IgM、IgA均正常,86.90％感染者CD3+、CD4+表达水平降低,CD8+表达水平相对稳定,CD4+/CD8+比值下降.结论 人芽囊原虫感染是慢性腹泻的一个重要病原体,其致病作用不容忽视.

Clinical analysis of Blastocystis hominis infection in 1185 patients with chronic diarrhea in 2011

Objective To study the prevalence status and clinical features of blastocystis hominis in patients with chronic diarrhea so as to provide a basis for prevention and control measures.Methods The stool specimens of 1 185 patients with chronic diarrhea who came to our hospital during Jan.2011 to Dec.2011 were extracted;meanwhile the patients＇ infection situation and laboratory test results were surveyed and analyzed.Results A total of 145 out of 1 185 cases were positive with the infection rate of 12.24%.The infection rate of those with mucilage,pus and blood stool is absolutely higher than those with other kinds of diarrhea（P0.001）.No significant difference was found among different groups of gender and age（P0.05）.And the farmer＇s infection rate is the highest.The laboratory test results showed the level of Hgb was lower（69.66%）,IgG、IgM、IgA were normal（80.69%′）.CD3＋/CD4＋ expression level were lower（86.90%）,CD8＋ expression level was relatively stable,and,CD4＋/CD8＋ was lower.Conclusion Blastocystis hominis is an important pathogen causing chronic diarrhea,whose pathopoiesis is not to be neglected.