| 盐酸苯海拉明凝胶的制备及质量控制 |
| |
| 引用本文： | 张广求,张美祥,郑锦秀. 盐酸苯海拉明凝胶的制备及质量控制[J]. 中国药房, 2005, 16(14): 1065-1067 |
| |
| 作者姓名： | 张广求 张美祥 郑锦秀 |
| |
| 作者单位： | 1. 湖北省黄冈市第一人民医院药剂科,黄冈市,438000
2. 湖北省黄冈市卫尔康医药有限公司,黄冈市,438000 |
| |
| 摘 要： | 目的:制备盐酸苯海拉明凝胶并建立其质量控制方法。方法:以羧甲基纤维素钠等作为凝胶基质,以正交试验筛选基质最佳配方,并采用紫外分光光度法在258nm波长处测定盐酸苯海拉明的含量。结果:制备的凝胶均匀细腻,分散性好;盐酸苯海拉明检测浓度在100～400μg/ml范围内线性关系良好(r=0.9999,n=6),平均回收率为99.95%,RSD=0.95%(n=9)。结论:该制剂质量稳定,质控方法可靠。
|
| 关 键 词： | 盐酸苯海拉明 凝胶 制备 质量控制 |
| 文章编号： | 1001-0408(2005)14-1065-03 |
| 修稿时间： | 2004-12-01 |
Preparation and Quality Control of Diphenhydramine Hydrochloride Gel |
| |
| ZHANG Guangqiu,Zhang Meixiang,Zheng Jinxiu. Preparation and Quality Control of Diphenhydramine Hydrochloride Gel[J]. China Pharmacy, 2005, 16(14): 1065-1067 |
| |
| Authors: | ZHANG Guangqiu Zhang Meixiang Zheng Jinxiu |
| |
| Abstract: | OBJECTIVE:To prepare diphenhydramine hydrochloride gel and establish its quality control.METHODS:The best formula was optimized by orthogonal design with sodium carboxymethyl cellulose and so on as the base materials,the content of diphenhydramine hydrochloride was determined by UV-spectrophotometry at the wavelength of258nm.REˉSULTS:The diphenhydramine hydrochloride gel was even,fine and which has a good dispersivity;In the concentration range of100～400μg/ml,the diphenhydramine hydrochloride had a linear relationship(r=0.9999,n=6),the average recovery was99.95%,RSD=0.95%(n=9).CONCLUSION:The preparation was stable in quality and reliable in quality control method. |
| |
| Keywords: | Diphenhydramine hydrochloride Gel Preparation Quality control |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
