| 蝙蝠葛酚性碱对实验性心肌缺血保护作用的研究 |
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| 引用本文： | 苏云明,李永强,周媛.蝙蝠葛酚性碱对实验性心肌缺血保护作用的研究[J].中国药师,2002,5(6):326-328. |
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| 作者姓名： | 苏云明 李永强 周媛 |
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| 作者单位： | 1. 黑龙江中医药大学药理教研室,150040
2. 哈尔滨市医药工业研究所 |
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| 基金项目： | 黑龙江省科技攻关项目“新药蝙蝠葛总碱粉针的研制”(GooC200801号) |
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| 摘 要： | 目的:研究蝙蝠葛酚性碱对实验性心肌缺血的保护作用。方法:结扎大鼠冠状动脉左前降支建立急性心肌缺血模型,监测标准Ⅱ导心电图;颈总动脉取血,测定血清超氧化物歧化酶(SOD)的活性,丙二醛(MDA)的含量,乳酸脱氢酶(LDH)及肌酸激酶(CK)的活性。结果:蝙蝠葛酚性碱可抑制ST段抬高幅度,增强超氧化物歧化酶(SOD)的活性,降低丙二醛(MDA)的含量和乳酸脱氢酶(LDH)、肌酸激酶(CK)的活性。结论 蝙蝠葛酚性碱对大鼠实验性心肌缺血具有保护作用,其机理可能与抗自由基生成,增强心肌耐缺血能力有关。
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| 关 键 词： | 心肌缺血 蝙蝠葛酚性碱 SOD MDA LDH CK |
| 文章编号： | 1008-049X(2002)06-0326-03 |
| 修稿时间： | 2002年1月19日 |
Research on Protective Effects of Phenolic Alkaloid of Menispermum Dauricum on Experimental Myocardial lschemia |
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| Su Yunming,Li Yongqiang.Research on Protective Effects of Phenolic Alkaloid of Menispermum Dauricum on Experimental Myocardial lschemia[J].China Pharmacist,2002,5(6):326-328. |
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| Authors: | Su Yunming Li Yongqiang |
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| Abstract: | Objective: To research a protective effect of phenolic alkaloid of menispermum dauricum on experimental myocardial ischemia. Method: A acute myocardial ischemia model was made through ligating the descending anterior branch of left coronary artery , the standard II -wire electrocardiogram was monitored, the blood in common carotid artery was drawn in order to determine actions of serum SOD,MDA,LDH,and CK. Result:The phenolic alkaloid of menispermum dauricum could inhibit the altitude of ST to rise , increase action of SOD and decrease actions of MDA, LDH, and CK. Conclusion: The phenolic alkaloid of menispermum dauricum have protective effect of experimental myocardial ischemia, the action mechanism may correlate with free radical generation and enhancement of myocardial anti-ischemia energy. |
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| Keywords: | Myocardial ischemia Phenolic alkaloid of menipermum dauricum SOD MDA LDH CK |
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