| HPLC法测定阿奇霉素分散片的含量 |
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| 引用本文： | 刘晓云,公方美. HPLC法测定阿奇霉素分散片的含量[J]. 齐鲁药事, 2005, 24(11): 668-669 |
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| 作者姓名： | 刘晓云 公方美 |
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| 作者单位： | 鲁南制药集团股份有限公司,临沂,276005 |
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| 摘 要： | 目的用高效液相色谱法测定阿奇霉素分散片的含量。方法以Hibar RT Pre-Packed柱为固定相,0.1mol.L-10.002M磷酸氢二铵溶液-异丙醇-乙腈(15∶25∶60,pH 9.2)为流动相,流速:1.0ml.min-1,紫外检测波长:210nm的条件下分离测定阿奇霉素分散片。结果阿奇霉素分散片在0.6~3mg.ml-1范围内,浓度与峰面积线性关系良好,r=0.9992,平均回收率为101.2%,RSD为0.8%。结论本法简便、迅速、灵敏度高、重现性好,可用于测定阿奇霉素分散片的含量。
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| 关 键 词： | 阿奇霉素 高效液相色谱法 含量测定 |
| 文章编号： | 1672-7738(2005)11-0668-02 |
Determination of Azithromycin Dispersible Tablets by HPLC |
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| Liu Xiao-yun,Gong Fang-mei. Determination of Azithromycin Dispersible Tablets by HPLC[J]. qilu pharmaceutical affairs, 2005, 24(11): 668-669 |
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| Authors: | Liu Xiao-yun Gong Fang-mei |
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| Abstract: | Objective To established a high performance liquid chromatography method for determination of azithromycin dispersible tablets.Methods Hibar RT Pre-Packed column was used,the mobile phase was 0.1mol·L~(-1) 0.002M diammonium hydrogen phosphate-isopropanol-acetonitrile(15∶25∶60,pH 9.2),flow rate was 1.0ml·min~(-1),UV detective wavelength was at 210nm.Results The linear range was 0.6～3mg·ml~(-1)(r=0.9992),the average recovery rate was 101.2%,RSD was 0.8%.Conclusion This method is simple,sensitive and reproducible.It can be used for detect the contents of azithromycin dispersible tablets. |
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| Keywords: | Azithromycin HPLC determination |
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