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| 中药复方双秦眼用凝胶体外释药性能 | |
| 引用本文： | 刘树扬,冯伟红,杜茂波,梁丽娜,葛克亚,刘淑芝. 中药复方双秦眼用凝胶体外释药性能[J]. 中国实验方剂学杂志, 2012, 18(8): 9-11 |
| 作者姓名： | 刘树扬 冯伟红 杜茂波 梁丽娜 葛克亚 刘淑芝 |
| 作者单位： | 1. 首都医科大学中医药学院,北京,100069 2. 中国中医科学院中药研究所,北京,100700 3. 中国中医科学院眼科医院,北京,100040 |
| 基金项目： | 重大新药创制科技专项(20092X09301-005) |
| 摘 要： | 目的:研究双秦眼用凝胶体外释放特性.方法:以秦皮甲素为指标,采用高效液相法进行含量测定；采用改良的Franz扩散池法,以半透膜为释放膜,研究双秦眼用凝胶的体外释放特性.结果:双秦眼用凝胶中秦皮甲素的释放以一级模型拟合较好,拟合方程Y=-1.2588 X-0.8162(r =0.9992).结论:双秦眼用凝胶释放为非Fick扩散. |
| 关 键 词： | 双秦眼用凝胶 释药性能 高效液相色谱法 Franz扩散池 秦皮甲素 |
| 收稿时间： | 2011-12-01 |
In vitro Releasing Property of Shuangqin Eye Gel |
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| LIU Shu-yang,FENG Wei-hong,DU Mao-bo,LIANG Li-n,GE Ke-ya and LIU Shu-zhi. In vitro Releasing Property of Shuangqin Eye Gel[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(8): 9-11 | |
| Authors: | LIU Shu-yang FENG Wei-hong DU Mao-bo LIANG Li-n GE Ke-ya LIU Shu-zhi |
| Affiliation: | College of Chinese Medicine, Capital Medicine University, Beijing 100069, China;Institute of Chinese Medicine, China Academy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Medicine, China Academy of Chinese Medical Science, Beijing 100700, China;Eye Hospital, China Academy of Traditional Chinese Medicine, Beijing 100040, China;College of Chinese Medicine, Capital Medicine University, Beijing 100069, China;Institute of Chinese Medicine, China Academy of Chinese Medical Science, Beijing 100700, China |
| Abstract: | Objective: To study on in vivo releasing characteristics of Shuangqin eye gel. Method: The content of aesculin was determined by HPLC,which was used as index;Modified Franz diffusion cell method was applied to investigate in vitro release characteristics of Shuangqin eye gel with semi-permeable membrane as a barrier. Result: Aesculin in Shuangqin eye gel released fitted well with first order model,fitting equation of it:Y=-1.258 8 X-0.816 2(r=0.999 2). Conclusion: Release of Shuangqin eye gel was non-Fick diffusion. |
| Keywords: | Shuangqin eye gel releasa performance HPLC Franz diffusion cell aesculin |
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