| 蟾酥制剂对大鼠三叉神经节及三叉神经脊束核尾侧亚核中P物质的影响 |
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| 引用本文： | 董文波,吴补领.蟾酥制剂对大鼠三叉神经节及三叉神经脊束核尾侧亚核中P物质的影响[J].牙体牙髓牙周病学杂志,2004,14(10):559-562. |
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| 作者姓名： | 董文波 吴补领 |
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| 作者单位： | 第四军医大学口腔医学院,陕西,西安,710032 |
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| 摘 要： | 目的：比较分析蟾酥制剂作用于牙髓后，三叉神经节(TG)和三叉神经脊束核尾侧亚核(Vc)内P物质(SP)的变化。方法：利用免疫组织化学染色方法，观察大鼠牙齿开髓封药0、1、2、4、6、24h后TG和Vc内sP的变化。结果：开髓1h时TG内阳性神经元的数目少于对照侧，4h后阳性神经元数量逐渐增多，接近正常。封药1h后Vc内密度低于对照侧，4h时密度明显高于对照侧，随后逐渐减低，至24h后已与对照侧密度一致。结论：蟾酥制剂可抑制TG内SP的合成和释放，Vc内三叉神经末梢释放SP减少。
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| 关 键 词： | 蟾酥制剂 三叉神经节 三叉神经脊束尾侧亚核 P物质 |
| 文章编号： | 1005-2593(2004)10-0559-04 |
| 修稿时间： | 2004年3月4日 |
The effect of toadvenom agents on P- substance in TG and Vc |
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| DONG Wen-bo,WU Bu-ling.The effect of toadvenom agents on P- substance in TG and Vc[J].Chinese Journal of Conservative Dentistry,2004,14(10):559-562. |
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| Authors: | DONG Wen-bo WU Bu-ling |
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| Abstract: | AIM:To compare and analyse changes of SP and CGRP in Vc and TG after toad venom agents was administrated in rat pulp.METHODS:To observe the change of SP and CGRP after toadvenom agents was administrated in rat pulp at different time points,i.e.,0,1,2,4,6,24 h by immunohistochemical technique.RESLUTS:In the 1h groups of the applying toadvenom,the positive fibers of SP and CGRP in TG and Vc decresed in comparison with the control group.After 4h,the positive fibers in TG increased and showed no difference with the control side,while the positive fibers in Vc were much more than that in the control group.Until 24 h,the positive fibers in Vc decreased to the level as that in the control group.CONCLUSION:Toad venom agents restrain the release and synthesize of SP in TG and Vc. |
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| Keywords: | Toadvenom TG Vc SP |
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