碳青霉烯类耐药肠杆菌科细菌无症状携带者主动筛查的研究进展*

碳青霉烯类耐药肠杆菌科细菌(CRE)的感染与传播是危害人类健康的公共问题。采取有效措施预防CRE感染是应对这种威胁的关键。住院患者肠道是耐药菌的储存库,这些定植的耐药菌具有引发院内感染暴发流行的潜在风险。CRE的定植常先于CRE的感染或与感染并存,对入院患者进行CRE的主动筛查并对阳性患者采取一定的措施是预防CRE感染与传播的有效途径。现在,越来越多的研究关注CRE的主动筛查。本文就CRE的流行现状、CRE主动筛查的人群及样本、筛查的方法等作简要综述。

Research progress on active screening for asymptomatic carriers of carbapenems-resistant Enterobacteriaceae

The infection and spread of carbapenem-resistant Enterobacteriaceae (CRE) are public problems that endanger human health. Taking effective measures to prevent CRE infection is the key to addressing this threat. Inpatient gut is a reservoir of resistant bacteria that have the potential to trigger a nosocomial infection outbreak. The colonization of CRE often precedes CRE infection or co-exist with infection, active screening of CRE and taking some measures to patients who colonized with CRE are effective ways to prevent CRE infection and transmission. Nowdays, more and more researchers focus on active screening of CRE. This article briefly reviews the prevalence of CRE, the population and the samples of active screening, and the screening methods.