Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role. |
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Authors: | M Wheatley S R Hawtin |
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Institution: | School of Biochemistry, University of Birmingham, UK. |
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Abstract: | Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a receptor which belongs to the large family of G-protein-coupled receptors (GPCR). Members of this family of receptor proteins are usually glycosylated on extracellular domains. In recent years the role of this glycosylation in cell surface expression/protein folding, ligand recognition and receptor-effector coupling has been investigated. This review summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), oxytocin (OT) and vasopressin (AVP). |
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Keywords: | glycosylation/glycohormone receptors/gonadotrophin-releasing hormone receptor/oxytocin receptor/vasopressin receptor |
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