TCTP、mTOR在胃癌中的表达意义

目的探讨人肿瘤翻译控制蛋白（TCTP）、哺乳动物雷帕霉素靶蛋白（mTOR）在胃癌组织中的表达并分析其与临床病理特征的关系．方法采用免疫组织化学法检测78例胃癌及10例正常胃组织中TCTP、mTOR的表达．结果胃癌组织中TCTP、mTOR蛋白的阳性表达率显著高于癌旁正常胃粘膜组织（P〈0．01），其表达水平与胃癌组织学分化类型、浸润深度、临床分期、淋巴结转移、远处转移明显相关（P〈0．05）；而与胃癌患者性别、年龄及肿瘤生长部位之间差异无统计学意义（P〉0．05）．胃癌患者组织分化程度越低、浸润深度越深、临床分期愈高，TCTP、mTOR表达阳性率愈高；且有淋巴结转移及远处转移者TCTP阳性表达率明显高于无转移者（P〈0．05）．生存期分析显示，TCTP、mTOR表达阳性者与阴性者生存时间比较差异有统计学意义（P〈0．05）．结论TCTP、mTOR的异常表达参与了胃癌的演进过程，可能是胃癌患者预后的一个独立指标之一．

The Expression and Significance of TCTP and mTOR in Human Gastric Carcinoma

Objective To explore the expression of tumor translation control protein （TCTP） and mammaliantarget of rapamy-cin （mTOR） in gastric carcinoma and analyze the relationships between TCTP, mTOR and clinicopathological features. Method The levels of TCTP and mTOR were detected from tissues of 78 gastric cancer patients and 10 normal people by immunohistochemical assay. Results Positive expression rate of TCTP and mTOR was significantly higher in gastric cancer tissues than in adjacent normal tissues. The expression level of TCTP and mTOR was significantly related to types of gastric tissue differentiation, depth of invasion, clinical stage, lymph node metastasis and distant metastasis, but not significantly related to patient sex, age and tumor location） . Patients with lower degree of differentiation, deeper invasion or higher clinical stage, the expression rates of TCTP and mTOR were higher. TCTP and mTOR expression rate of patients with lymph node and distant metastasis was significantly higher than those of without lymph node and distant metastasis. Survival analysis showed that survival time of patients with positive expression rate of TCTP and mTOR and with negative expression rate of TCTP and roTOR had statistically significant difference. Conclusion The abnormal expression of TCTP and mTOR is involved in the evolution of gastric cancer, and is an independent prognostic indicator for gastric cancer patients.