| E-cadherin对非小细胞肺癌的转移和靶向治疗的影响 |
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| 引用本文： | 周喆焱. E-cadherin对非小细胞肺癌的转移和靶向治疗的影响[J]. 昆明医学院学报, 2014, 35(4): 164-167 |
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| 作者姓名： | 周喆焱 |
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| 作者单位： | 周喆焱 (昆明医科大学基础医学院病理学教研室,云南 昆明,650500)； |
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| 基金项目： | 国家自然科学基金资助项目(项目编号：81060189),云南省自然科学基金资助项目(项目编号：2010ZC107) |
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| 摘 要： | E-cadherin是维持上皮细胞极性和上皮完整性的重要分子，也是细胞上皮表型的主要标志．在肿瘤发生侵袭和转移的过程中上皮一间质转化（epithehal—mesenchymal transition，EMT）起了重要的作用，E-cadherin蛋白的表达缺失是EMT发生的主要标志．E-cadherin的异常表达对非小细胞肺癌的转移及患者的靶向治疗效果均有影响，就E-cadherin在非小细胞肺癌的转移和靶向治疗中的作用进行综述．
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| 关 键 词： | E-cadherin 非小细胞肺癌 转移 分子靶向治疗 |
Impact of E-cadherin on Metastasis and Molecular Targeted Therapy in Non-small Cell Lung Cancer |
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| Affiliation: | ZHOU Zhe-yan , RUAN Rui , BIAN Li (1) Dept. of Pathology, School of Basic Medicine Kunming Medical University, Kunming Yunnan 650500; 2) Dept. of Orthopedics; 3) Dept. of Pathology, The 1st Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650032, China) |
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| Abstract: | E-cadherin is a key molecule in maintaining cell polarity and epithelial integerity, and it is themain symbol of epithelial phenotype. The process of epithelial-mesenchymal transition （EMT） plays a critical role in the invasion and metastasis of tumor, while the deletion of E-cadherin protein expression is a defining characteristic of EMT. The abnormal expression of E-cadherin is associated with both metastasis and molecular targeted therap metastasis and y of patients with non-small ceil lung cancer. This review summarizes the relation of E-cadherin with molecular targeted therapy in non-small cell lung cancer. |
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| Keywords: | E-cadherin Carcinoma Non-small-cell lung Metastasis Molecular targetedtherapy |
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