| 慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系研究 |
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| 引用本文： | 李晖,杨永锐,杨晓冬,汪亚玲,何越峰. 慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系研究[J]. 昆明医学院学报, 2014, 0(2): 80-82 |
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| 作者姓名： | 李晖 杨永锐 杨晓冬 汪亚玲 何越峰 |
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| 作者单位： | 李晖 (昆明市第三人民医院,云南昆明,650041)； 杨永锐 (昆明市第三人民医院,云南昆明,650041)； 杨晓冬 (昆明市第三人民医院,云南昆明,650041)； 汪亚玲 (昆明市第三人民医院,云南昆明,650041)； 何越峰 (昆明医科大学公共卫生学院劳动卫生与环境卫生系,云南昆明,650500)； |
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| 基金项目： | 昆明市卫生局科研基金资助项目(项目编号：2010-05) |
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| 摘 要： | 目的：探讨慢性乙型肝炎患者血浆脂氧素A4水平与疾病临床分度的关系．方法选取病毒性肝炎乙型慢性轻度患者34例、慢性中度患者30例，慢性重度患者30例，采集患者外周静脉血分离血浆，应用酶联免疫方法测定血浆脂氧素A4的含量，分析脂氧素A4与慢性乙型肝炎临床分度的关系．结果慢性重度肝炎患者外周血脂氧素A4水平显著低于慢性轻度患者和慢性中度患者（P〈0.05），和疾病临床分度显著相关．外周血血浆脂氧素A4的含量与ALT和AST的水平均成负相关，相关系数为分别为＝-0.41，＝0.019和＝-0.37，＝0.034．结论外周血血浆脂氧素A4的含量与慢性乙型肝炎临床分度相关．
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| 关 键 词： | 脂氧素A4 肝炎乙型 肝炎病毒乙型 临床分度 Lipoxin A4 |
Correlation of Serum Lipoxin A4 with Clinical Grading of Chronic Hepatitis B Patients |
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| LI Hui,YANG Yong-rui,YANG Xiao-dong,WANG Ya-ling,HE Yue-feng. Correlation of Serum Lipoxin A4 with Clinical Grading of Chronic Hepatitis B Patients[J]. Journal of Kunming Medical College, 2014, 0(2): 80-82 |
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| Authors: | LI Hui YANG Yong-rui YANG Xiao-dong WANG Ya-ling HE Yue-feng |
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| Affiliation: | 1 Dept. of Liver Diseases, The Third People＇s Hospital of Kunming, Kunming Yunnan 650041 ; 2 Dept. of Occupational and Environmental Health, School of Public Health, Kunming Medical Hniversity, Kunming Yunnan 650500, China) |
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| Abstract: | Objective To explore the correlation between serum Lipoxin A4 and clinical grading of chronic hepatitis B patients. Method The serum Lipoxin A4 was detected by Enzyme-Linked Immunosorbent Assay in 94 chronic hepatitis B patients. Results It was found that the level of serum Lipoxin A4 of severe hepatitis patients were significantly lower than mild hepatitis patients and moderate hepatitis patients （ =0.04 and =0.03） . The serum Lipoxin A4 levels were correlated negatively with the ALT and AST levels,respectively =-0.41, =0.019 and R=-0.37,P=0.034. Conclusion These findings support the fact that the serum Lipoxin A4 may contribute to clinical grading of chronic hepatitis B patients. |
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| Keywords: | Hepatitis B Hepatitis Virus B Clinical grading |
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