无症状乙型肝炎表面抗原阳性患者206例丙氨酸转氨酶异常临床分析

目的了解无症状乙型肝炎表面抗原(HBsAg)阳性者丙氨酸转氨酶(ALT)及乙型肝炎病毒复制的情况。方法对206例无症状HBsAg阳性者进行ALT、乙型肝炎五项及乙型肝炎病毒脱氧核糖核酸(HBV-DNA)的检测。结果无症状HBsAg阳性者中有19.9%的患者存在ALT的异常,但造成ALT异常的因素与性别差异无关;在ALT异常的无症状HBsAg阳性者中HBV-DNA的阳性率为68.2%。结论对于临床无症状的HBsAg阳性人群应定期检查,做到早发现、早治疗,以延缓疾病进展,减少肝硬化、原发性肝癌的发生。

Analysis of abnormal occurrence of alanine transaminase in 206 asymptomatic positive persons of hepatitis B surface antigen

Objective To understand the condition of alanine transaminase(ALT) and virus replication in asymptomatic persons whose HBsAg were positive.Methods ALT,the markers of hepatitis B virus(HBVM) and deoxyribonucleic acid of hepatitis B virus(HBV-DNA) were measured in 206 asymptomatic persons whose HBsAg were positive.Results Abnormal rate of ALT in this group was 19.9%,the sex difference was not related to abnormality of ALT.But there was a higher positive rate of HBV-DNA(68.2%) in asymptomatic positive persons of HBsAg whose ALT was abnormal.Conclusion In order to discover and treat liver damage in time,periodic inspection of ALT,HBVM and HBV-DNA should be carried out in asymptomatic persons whose HBsAg were positive.