常、微量元素与胎儿宫内发育迟缓关系的研究

目的 探讨常、微量元素与胎儿宫内发育迟缓(IUGR)间的关系.方法 孕晚期测定71名孕妇母血、脐血、羊水中微量元素水平,其中IUGR组21例,对照组35例,巨大儿组15例.结果 IUGR组母血清Zn,Se,Mn,Fe,Mg,Cr明显低于对照组(P＜0.05);Cd,Pb,Ni水平明显高于对照组;巨大儿组母血清Fe含量亦明显低于对照组(P＜0.05);三组间Ca,Ti,Co,Li无明显差别.IUGR组脐血清Se,Mn,Cd,Fe,Cu,Mg明显低于对照组;Pb,Ni明显高于对照组;三组间Zn,Ca,Ti,Co,Li无明显差别.IUGR组羊水Zn,Se,Mn,Fe明显低于对照组,三组间Ca,Co无明显差别.结论 常、微量元素与胎儿发育关系密切,Zn,Se,Mn,Fe,Mg,Cu,Cr缺乏可致胎儿宫内发育迟缓,Cd,Pb,Ni升高可致低体重儿.

Observation of the relationship between macro/microelements and Intrauterine Growth Retardation

Objective To study the relationship between macro/microelements and Intrauterine Growth Retardation. Methods Microelements were analyzed in maternal blood, cord serum and amniotic fluid of 71 gravidas during late pregnancy, which were divided into IUGR group (n = 21), normal birth weight (control group, n = 35) and macrosomia group (n=15) respectively. Results In maternal blood of IUGR group, the levels of Zn, Se, Mn, Fe, Mg, and Cr were significantly lower than that of control group (P<0. 05); the levels of Cd, Pb, and Ni were significantly higher than that of control group; Fe in macrosomia group was significantly lower than that of control group(P<0. 05); Ca, Ti, Co, and Li had no apparently difference in the three groups. In cord serum of IUGR group, the levels of Se, Mn, Cd, Fe , Cu, and Mg were significantly lower than that of control group; Pb, Ni were significantly higher than that of control group; Zn, Ca, Ti, Co, and Li had no significant difference in the three groups. In amniotic fluid of IUGR group, the levels of Zn, Se, Mn, and Fe were significantly lower than that of control group; Ca and Co had no significant difference in the three groups. Conclusion Some macro and microelements have close relationship with fetal growth. The deficiency of Zn, Se, Mn, Fe, Mg, Cu, and Cr can lead to IUGR, while excess Cd, Pb, and Ni may result in low birth weight.