| 壮、汉族HLA—DRB1＊07基因与乙肝疫苗应答相关性对比研究 |
| |
| 引用本文： | 龚星光,吴继周,韦颖华,李国坚,陈茂伟,吴健林,万裴琦,孟艳丽,胡蝶飞,虞艳琦.壮、汉族HLA—DRB1＊07基因与乙肝疫苗应答相关性对比研究[J].内科,2009,4(2):181-184. |
| |
| 作者姓名： | 龚星光 吴继周 韦颖华 李国坚 陈茂伟 吴健林 万裴琦 孟艳丽 胡蝶飞 虞艳琦 |
| |
| 作者单位： | 广西医科大学第一附属医院感染性疾病科,南宁市,530021 |
| |
| 基金项目： | 广西壮族自治区卫生厅自筹课题(Z2005062);;广西自然科学基金课题(桂科自0728159) |
| |
| 摘 要： | 目的对比广西壮、汉民族HLA-DRB1＊07基因与乙肝疫苗免疫应答的相关性。方法以广西73名壮族、97名汉族健康大学生作为研究对象进行全程乙肝疫苗接种，采用PCR—SSP技术检测受试者外周血细胞DNA的HLA—DRB1＊07基因，采用ELISA方法检测其血清乙肝病毒标志物（HBsAg，抗-HBs，HBeAg，抗-HBe，抗-HBc）。结果壮族与汉族之间乙肝疫苗的应答率无显著性差别（84．21％V886．60％，P=0．658），壮族与汉族人群之间HLA-DRB1＊07基因携带频率的差异也无统计学意义（9．21％vs6．19％。P=0．454），但壮、汉族中HLA—DRB1＊07携带者的疫苗应答率都显著低于非携带者（P=0．00／P=0．03）。结论民族差异不是广西人群乙肝疫苗应答效果的影响因素；广西壮、汉族人中携带HLA—DRB1＊07基因都可能是导致机体对乙肝疫苗无／弱应答的因素。
|
| 关 键 词： | 民族 HLA—DRB1＊07基因 乙肝疫苗 免疫应答 |
Comparative study of relationship between HLA-DRB1*07 gene and immune response to hepatitis B vaccine in Zhuang and Han nationality from Guangxi |
| |
| GONG Xing-guang,WU Ji-zhou,WEI Ying-hua,LI Guo-jian,CHEN Mao-wei,WU Jian-lin,WAN Pei-ji,MENG Yan-Li,HU Die-fei,YU Yan-qi.Comparative study of relationship between HLA-DRB1*07 gene and immune response to hepatitis B vaccine in Zhuang and Han nationality from Guangxi[J].Internal Medicine of China,2009,4(2):181-184. |
| |
| Authors: | GONG Xing-guang WU Ji-zhou WEI Ying-hua LI Guo-jian CHEN Mao-wei WU Jian-lin WAN Pei-ji MENG Yan-Li HU Die-fei YU Yan-qi |
| |
| Institution: | the First Affiliated Hospital of Guangxi Medical University;Nanning 530021;China |
| |
| Abstract: | Objective To investigate the relationship between HLA-DRB1*07 gene and the feature of immune response to hepatitis B vaccine among Zhuang and Han nationality from Guangxi.Methods 76 healthy college students of Zhuang and 97 of Han nationality from Guangxi autonomous region were received standard courses of vaccination with hepatitis B vaccine.HBV makers(HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc) of the subjects were tested with ELISA.HLA-DRB1*07 was detected with PCR-SSP.Result No significant difference was sh... |
| |
| Keywords: | Nationality HLA-DRB1*07 Hepatitis B vaccine Immune response |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
