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| 核糖核酸干扰 | |
| 引用本文： | 孔祥平. 核糖核酸干扰[J]. 中国病理生理杂志, 2004, 20(5): 900-903 |
| 作者姓名： | 孔祥平 |
| 作者单位： | 1. 广州空军医院全军肝病中心, 广东 广州 510602; 2. Department of molecular-biology, University of Missouri-Columbia |
| 摘 要： | The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system , RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA (dsRNA) directs sequence - specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21 - and 23 - nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years,the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology. |
| 关 键 词： | RNA 双链 RNA干扰 |
| 文章编号： | 1000-4718(2004)05-0900-04 |
| 收稿时间： | 2002-11-11 |
The RNA interference |
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| KONG Xiang-ping,Lixing W. Reneker. The RNA interference[J]. Chinese Journal of Pathophysiology, 2004, 20(5): 900-903 | |
| Authors: | KONG Xiang-ping Lixing W. Reneker |
| Affiliation: | 1. The Research Center of Liver Diseases, PLA Air force Hospital, Guangzhou 510602, China; 2. Department of molecular-biology, University of Missouri-Columbia |
| Abstract: | The phenomenon of RNA interference (RNAi) is highly conserved mechanism in the organism evolution. As a immune system ,RNAi is a ubiquitous mechanism against invading microorganism in plant and animal cells. Recently, it has been found that RNAi is the process by which double-strand RNA(dsRNA) directs sequence-specific degradation of messenger RNA and the mediations of sequence specific messenger RNA degradation are 21-and 23-nucleotide small interfering RNAs that generate by ribonuclease from endogenous longer dsRNA or by transfectious technics from heterologous dsRNA. Over the past few years, the way in which cells respond to dsRNA by silencing homologous genes has revealed a new regulating paradigm in biology. |
| Keywords: | RNA double-stranded RNA interference |
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