Analysis of zinc and other elements in rat pancreas,with studies in acute pancreatitis |
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| Authors: | Mikiya Kashiwagi Hiroshi Akimoto Junko Goto Teruaki Aoki |
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| Affiliation: | 1. Department of Surgery, Jikei University, School of Medicine, 3-25-8, Nishishinbashi, Minato-ku, 105, Tokyo, Japan
2. Department of Textile and Clothing, Kyoritsu Women's University, 2-2-1, Hitotsubashi, Chiyoda-ku, 101, Tokyo, Japan
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| Abstract: | Determination of the concentration of certain elements makes it possible to investigate the physiology of the pancreas: We used X-ray fluorescence to determine the concentrations of zinc and other elements in the pancreas of normal (control) rats and those with cerulein-induced pancreatitis. Ten elements (Zn, Ni, Fe, P, Ca, Cl, S, K, Ti, and Mn) were detected in controls. In the early stage of acute pancreatitis, the pancreatic concentrations of Zn, Ni, Fe, and P were significantly decreased (P<0.05) and=" those=" of=" ca=" and=" cl=" were=" significantly=" increased=">P<0.05), compared=" with=" control=" levels.=" however,=" levels=" of=" s,=" k,=" and=" ti=" did=" not=" differ=" significantly=" from=" the=" control=" values.=" mn=" was=" detected=" in=" only=" some=" samples.=" the=" serum=" levels=" of=" zn=" and=" fe=" were=" significantly=" elevated=">P<0.05) in=" acute=" pancreatitis.=" these=" observations=" indicate=" that=" zn=" and=" these=" other=" nine=" elements=" could=" play=" an=" important=" role=" in=" acute="> |
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| Keywords: | acute pancreatitis X-ray fluorescence zinc elements |
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