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| 2型糖尿病患者认知功能受损与血清脑源性神经营养因子的相关性 | |
| 引用本文： | 周东浩,房 辉,秦 静,姚会军,王江东,周明爱,张向阳. 2型糖尿病患者认知功能受损与血清脑源性神经营养因子的相关性[J]. 中国康复医学杂志, 2010, 25(4): 315-318. DOI: 10.3969/j.issn.1001-1242.2010.04.005 |
| 作者姓名： | 周东浩 房 辉 秦 静 姚会军 王江东 周明爱 张向阳 |
| 作者单位： | 1. 河北医科大学,050017 2. 河北医科大学,050017;河北医科大学唐山工人医院 3. 济南军区青岛第二疗养院全军神经疾病诊疗康复中心 4. 河北医科大学唐山工人医院 5. 山东省临沂市中,医医院 6. 北京回龙观医院 |
| 摘 要： | 目的:研究2型糖尿病患者认知功能变化和血清脑源性神经营养因子(BDNF)水平的关系。方法:2型糖尿病组144例,正常对照120例,调查所有受试的人口学资料和临床资料,并进行重复性成套神经心理状态测验(RBANS),ELISA检测血清脑源性神经营养因子水平。结果:2型糖尿病组和正常对照组相比,在认知标准化总分、言语功能、即刻记忆、延时记忆和注意功能方面明显下降(P0.01)。2型糖尿病患者血清BDNF水平低于正常(P0.01)。这种BDNF的变化与2型糖尿病患者的认知标准化总分、即刻记忆、视觉广度、延时记忆和注意功能下降相关,调整年龄、性别、文化程度等影响因素后,血清BDNF水平与认知标准化总分、延时记忆和注意功能的关联依然显著(校正后P总=0.039;P延时=0.025;P注意=0.013)。结论:2型糖尿病患者存在认知功能损伤,这种认知损伤,尤其是注意和延时记忆功能下降与血清BDNF降低有关。 |
| 关 键 词： | 脑源性神经营养因子 糖尿病 认知障碍 重复性成套神经心理状态测验 |
| 收稿时间： | 2009-12-04 |
The association between serum brain-derived neurotrophic factor level and cognitive decline in patients with type 2 diabetes |
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| ZHOU Donghao,FANG Hui,YAO Huijun,et al.. The association between serum brain-derived neurotrophic factor level and cognitive decline in patients with type 2 diabetes[J]. China Journal of Rehabilitation Medicine, 2010, 25(4): 315-318. DOI: 10.3969/j.issn.1001-1242.2010.04.005 | |
| Authors: | ZHOU Donghao FANG Hui YAO Huijun et al. |
| Affiliation: | Hebei Medical University, Shi-Jiazhuang, 050017 |
| Abstract: | Objective:To explore the association between serum brain-derived neurotrophic factor (BDNF) level and cognitive dysfunction in patients with type 2 diabetes mellitus(T2DM). Method: The 144 patients with known T2DM were compared with 120 age-sex and education matched, non-dia-betic controls. Cognitive function was assessed by using the repeatable battery for the assessment of neuropsycholo-gieal status(RBANS)test. Serum BDNF level was tested by ELISA. Result: In the RBANS test, patients differed significantl... |
| Keywords: | brain-derived neurotrophic factor diabetes cognitive dysfunction repeatable battery for the assessment of neuropsychologieal status |
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