从微循环变化评价血活素对心肌缺血的保护作用

目的从细胞代谢促进剂(血活素)对微循环-血流变影响的研究中评价该药物对缺血性心脏病的治疗作用.方法123例缺血性心脏病病人随机分为两组,对照组60例,常规应用硝酸甘油治疗;治疗组63例,在常规治疗基础上用血活素注射液10ml加入200ml生理盐水中,静脉滴注,1次/日,共14天.两组在治疗前后均测定甲襞微循环(包括输入输出枝长度、管径、流速、袢顶面积)和血液流变学(包括高低切全血粘度、血浆粘度、红细胞变形指数及电泳时间、血小板粘附率)等指标.结果血活素治疗组病例在改善微血管状态和流态、全血粘度、红细胞变形指数及电泳时间等方面较对照组有更加显著的效果.结论细胞代谢促进剂(血活素)对缺血性心脏病有良好的治疗作用,病情的好转和微循环-血流变指标的改善呈一致性.

Assessment of Protective Effect of Blood Polypeptide on Myocardial Ischemia by Change of Microcirculation Hemorheology

To appraise the curative effect of the drug on ischemic heart disease by study the effect of cell metabolic promoter (blood active polypeptide) on hemorheology and microcirculation. Methods: 123 patients with ischemic heart disease were randomly divided into 2 groups. 63 cases of treatment group among them were taken blood active polypeptide injection 10ml 0.9% sodium chloride iv. qd. for 14d. Other 60 cases were in control group. Nailfold microcirculation (length, diameter, flow velocity of loop input and output branch and apical area) and hemorheology (whole blood viscosity in high and low shearing rate, plasma specific viscosity, RBC deformation index, RBC electrophoresis time and platelet adhesion rate) were measured before and after treatment. Results: The indices of microvessel state and fluid, whole blood viscosity, RBC deformation index and electrophoresis time in the treatment group have improved significantly comparing with those in the control group. Conclusion: Cell metabolic prompter might be very effective to ischemic heart disease which is interrelated to microcirculation and hemorheology.