乳腺癌组织中PCNA和Cath—D的表达及相关性研究

目的：探讨Cath—D、PCNA在乳腺癌中表达的意义及相关性。方法：应用免疫组化S—P法检测49例乳腺癌中Cath—D、PCNA的表达情况，并与35例乳腺良性病变进行对照分析。结果：乳腺良性病变Cath—D、PCNA的阳性率分别为17．1％（6／35）、28．6％（10／35）。乳腺癌Cath—D、PCNA的阳性率分别为53％（26／49）、73．5％（36／49），差异具有统计学意义（P〈0．05）。乳腺癌Cath—D的表达与年龄无关（P〉0．05），与组织学分级相关（P〈0．05）；PCNA的表达与年龄、组织学分级均无关（P〉0．05）。乳腺癌Cath—D、PCNA的表达呈正相关（P〈0．05）。结论：Cath—D、PCNA表达异常在乳腺癌的发生、发展中具有重要的作用，两者具有相互作用。Cath—D、PCNA可用于良、恶性乳腺疾病的鉴别，对乳腺良性病变的恶性转化有-定的预兆性。

expression and correlation of Cath -D , PCNA in breast carcinoma

Objective：To study the expressions and correlation of Cath - D and PCNA in breast carcinomas. Methods ： The expressions of Cath - D and PCNA were studied in 49 cases of breast carcinoma by immumohistoehem- ical technology ,35 cases of benign lesions served as control. Results：Positive rates of Cath- D , PCNA in breast be- nign lesions were 17.1% （6/35 ） ,28.6 % （ t0/35 ） respectively. Positive rates of Cath - D ,PCNA in breast carci- nomas were 53 % （26/49） ,73.5 % （36/49） ,respectively. Positive rates of Catb - D,PCNA in breast benign le- sions and in breast carcinomas had significant difference （ P 〈 0.05 ） . The expression of Cath - D in breast carcino- mas did not correlate with age （ P 〉 0.05 ） . But expression of Cath - D in breast carcinomas was associated wit h hi- tological grading （ P 〈 0.05 ） , the expression of PCNA in breast carcinomas did not correlate with age , histological grading （ P 〉 0.05 ） . There was a positive correlation between the expressions of p27 and PCNA in breast carcinomas （ P 〈 0.05 ）. Conclusion： Abnormal expression of Cath - D , PCNA play an important role initiation and development of breast carcinomas. Cath - D , PCNA interact with one another in breast carcinomas. Catb - D,PCNA can be used to identify benign and malignant breast disease. There is some significance of prediction as malignant change of breast benign lesions.