| 2-(2-(3-(2-(7-氯-2-喹啉基)乙烯基)苯基)-3-氧代丙基)苯基丙醇的合成工艺 |
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| 引用本文： | 余 茜,杨显辉.2-(2-(3-(2-(7-氯-2-喹啉基)乙烯基)苯基)-3-氧代丙基)苯基丙醇的合成工艺[J].沈阳药科大学学报,2014(3):184-187. |
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| 作者姓名： | 余 茜 杨显辉 |
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| 作者单位： | ;1.郑州人民医院药学部;2.郑州铁路职业技术学院药学系 |
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| 摘 要： | 目的对2-(2-(3-(2-(7-氯-2-喹啉基)乙烯基)苯基-3-氧代丙基)苯基)丙醇的合成工艺进行研究。方法以间氰基苯甲醛和邻甲基苯乙酮分别作为起始原料,经过缩合、格氏反应、羟基保护、羟甲基反应、卤化反应,缩合得到最终目标产物。结果总收率为质量分数47.5%。结论该工艺原料易得,降低了制备成本、简化了反应操作条件、提高了产率,更适合工业化生产。
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| 关 键 词： | 格氏反应 缩合 合成 |
Synthesis of 2-(2-(3-(2-(7-chloroquinolin-2-yl) vinyl) phenyl)-3-oxopropyl) phenyl) propyl alcohol |
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| Abstract: | Objective To study the synthetic technology of 2-( 2-( 3-( 2-( 7-chloroquin-olin-2-yl) vinyl) phenyl)-3-oxopropyl) phenyl) propyl alcohol. Methods Taking 3-cyanobenzaldehyde and methyl acetophenone as the starting material,target compound w as obtained after a series of chemical reactions including condensation reaction,Grignard reaction,hydroxyl protection,hydroxymethyl reaction,halogenation reaction,and condensation reaction. Results The overall yield w as 47. 5%. Conclusions The improved procedure can low er the cost of preparation,simplify the reaction operating conditions,increase the yield,and make it more suitable for the industrial requirements. |
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| Keywords: | Grignard reaction condensation reaction synthesis |
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