Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome |
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| Authors: | Jeffrey S. Chamberlain Stephen G. Grant Alice A. Reeves Linda J. Mullins Dennis A. Stephenson Eric P. Hoffman Anthony P. Monaco Louis M. Kunkel C. Thomas Caskey Verne M. Chapman |
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| Affiliation: | (1) Institute for Molecular Genetics, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, Texas;(2) New York State Department of Health, Roswell Park Memorial Institute, 14263 Buffalo, New York;(3) Division of Genetics, Department of Pediatrics, Harvard Medical School Children's Hospital, 02115 Boston, Massachusetts;(4) The Program in Neuroscience, Harvard University, 02138 Cambridge, Massachusetts |
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| Abstract: | The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice. |
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