相关因素对血清前列腺特异性抗原(PSA)影响的临床意义

目的　探讨相关因素对血清前列腺特异性抗原 (PSA)影响的临床意义。方法　前瞻性随机分析 138例前列腺病变患者 ,了解直肠指诊、留置尿管、前列腺穿刺活检和前列腺手术对血清PSA的影响以及影响程度。结果　本组 138例前列腺病变患者 ,直肠指诊对血清PSA值的改变差异无显著性 (P >0 0 5 ) ;其中 70例前列腺穿刺活检对血清PSA的改变差异有显著性 (P <0 0 1) ;32例前列腺手术对血清PSA值的改变差异有显著性 (P <0 0 1) ;15例留置尿管病例使血清PSA值明显升高 ,行前列腺手术后 ,血清PSA值却明显下降 (P <0 0 1)。结论　直肠指诊检查对血清PSA值的改变无影响 ,前列腺活检使血清PSA值升高 1 4倍。前列腺手术使血清PSA值升高 1 8倍。急性尿潴留使血清PSA值升高 3 5倍 ,前列腺手术后血清PSA值下降 1 6倍

Clinical Significance of Correlation Factors on Serum PSA Concentration

Objective To evaluate clinical significance of the effect of rectal examination, needle biopsy and prostatectomy on serum prostate specific antigen(PSA) concentration.Methods A total of 138 patients who presented prostatic problems (BPH, prostate cancer and prostatitis) were studied prospectively,the effects of digital rectal examination (DRE), the bladder catheterized, prostate biopsy and prostatectomy on serum PSA concentration were observed.Results The DRE had not clinical significant effect on serum PSA concentration of 138 patients with prostatic problems (P>0 05). 70 of 138 patients had serum PSA concentration remarkable elevation after prostate biopsy (P<0 01), and 32 patients with BPH had serum PSA obviously concentration elevation after prostatectomy (P<0 01). 15 of 138 patients had serum PSA concentration significantly elevation when the bladder was catheterized, and serum PSA was significantly lowed by prostatectomy (P<0 01).Conclusions DRE had not clinical significant effect on serum PSA concentration. We note a 1 4-fold increase in the post-prostate biopsy on serum PSA concentration, and which had a 1 8-fold increase after prostatectomy. It was a 3 5-fold increase on serum PSA concentration when the bladder was catheterized,and which was a 1.6-fold decrease after prostatectomy.