新的抗肝癌分子靶及相关药物研究

目前临床上有效的抗肝癌药物很少,普遍存在着疗效差、毒性大、易产生耐药性等问题,发现新的肝癌分子靶,并以此发展高效低毒的抗肝癌药物是解决问题的关键之一。相关研究表明启动子甲基化、肝细胞生长因子及其受体、血管内皮生长因子及其受体、环氧化酶 2可能是抗肝癌药物有效的分子靶,相应的配体化合物已展示了潜在的应用前景。此外三氧化二砷等其他类型的化合物也显示了一定的抗肝癌疗效。

New molecular targets and novel agents for human hepatoma

Current anti-hepatoma agents in clinical aplication have not been proved to be satisfactory. The major obstacles are low efficacy, toxicity, and drug resistance. Identifying new drug targets and discovering new agents accordin gly with high efficacies and low toxicities have become the key part of the solu tion. Recent studies have shown that hyper-methylation of tumor suppressor gene s, interaction between hepatocyte growth factor and its receptor, vascular endothelial growth factor and its receptor, as well as cyclooxygenase-2 might be potential targets for hepatomachemotherapy. Indeed, agents acting on these targets have shown to be effective. In addition, other agents such as As 2O 3 have also shown th eir activities against hepatoma.