| 鼻息肉中转化生长因子β1的表达和意义 |
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| 引用本文： | 郭剑锋 刘美莲 王向东 陶呼 张呼和 韩德民 诸小侬. 鼻息肉中转化生长因子β1的表达和意义[J]. 临床耳鼻咽喉头颈外科杂志, 2001, 15(5): 206-208 |
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| 作者姓名： | 郭剑锋 刘美莲 王向东 陶呼 张呼和 韩德民 诸小侬 |
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| 作者单位： | 郭剑锋（内蒙古医学院第一附属医院耳鼻咽喉科呼和浩特，010050）;刘美莲（内蒙古医学院第一附属医院耳鼻咽喉科呼和浩特，010050）;王向东（北京市耳鼻咽喉研究所）;陶呼（内蒙古医学院第一附属医院耳鼻咽喉科呼和浩特，010050）;张呼和（内蒙古医学院第一附属医院耳鼻咽喉科呼和浩特，010050）;韩德民（北京市耳鼻咽喉研究所）;诸小侬（北京市耳鼻咽喉研究所） |
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| 摘 要： | 目的探讨转化生长因子β
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| 关 键 词： | 鼻息肉；转化生长因子β |
| 文章编号： | 1001-1781(2001)05-0206-03 |
| 修稿时间： | 2000-08-18 |
Expression andsignificance of TGF- |
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| GUO Jianfeng. Expression andsignificance of TGF-[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2001, 15(5): 206-208 |
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| Authors: | GUO Jianfeng |
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| Affiliation: | First Affiliated Hospital of Inner Mongolia Medical College, Huhehaote 010050. |
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| Abstract: | OBJECTIVE: To study the expression and significance of transforming growth factor-beta 1(TGF-beta 1) in nasal polyps. METHOD: Expression of TGF-beta 1 in nasal polyps from 34 patients and middle turbinates from 30 patients with deviation of nasal septum were prospectively studied with immunohistochemistry. Each tissue section was observed under optical microscope. RESULT: 1. The TGF-beta 1 positivity in extracellular matrix and in cells in the stroma was significantly higher in nasal polyps than in middle turbinates (P < 0.01). 2. The distribution and shape of TGF-beta 1 expressing cells in nasal polyps was similar to that of eosinophil, their positivities were significantly correlative (P < 0.05). 3. The positivity of TGF-beta 1 did not correlate with clinical type of nasal polyps (P > 0.05), eosinophil infiltration correlated significantly with clinical type of nasal polyps(P < 0.05). CONCLUSION: 1. The TGF-beta 1 may contribute to some of the pathologic changes observed in nasal polyps, such as thickening of the epithelial basement membrane and stromal fibrosis. 2. Eosinophils in nasal polyps represent a major source of TGF-beta 1. 3. Eosinophils infiltration may play a prominent role in the development and recurrence of nasal polyps. |
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